SRR8392892
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.300
- PANCREAS_BETA_CELLS+0.290
- ALLOGRAFT_REJECTION+0.280
- INTERFERON_ALPHA_RESPONSE+0.270
- INTERFERON_GAMMA_RESPONSE+0.140
- SPERMATOGENESIS+0.140
- MYOGENESIS+0.120
- COAGULATION+0.080
- INFLAMMATORY_RESPONSE-0.020
- XENOBIOTIC_METABOLISM-0.040
Top 10 suppressed
- TGF_BETA_SIGNALING-0.560
- WNT_BETA_CATENIN_SIGNALING-0.500
- PROTEIN_SECRETION-0.480
- UNFOLDED_PROTEIN_RESPONSE-0.470
- MYC_TARGETS_V1-0.450
- MTORC1_SIGNALING-0.430
- MITOTIC_SPINDLE-0.410
- TNFA_SIGNALING_VIA_NFKB-0.390
- UV_RESPONSE_DN-0.390
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.370
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-49-AAR2-01A-11R-A39D-07 | — | cohortA3 | 0.936 |
| 2 | TCGA-49-AARQ-01A-11R-A41B-07 | — | cohortA1 | 0.918 |
| 3 | SRR33346946 | — | — | 0.913 |
| 4 | SRR8942994 | — | — | 0.904 |
| 5 | MDT-AP-1327 | Med | Medulloblastoma | 0.899 |
| 6 | SRR12202406 | — | — | 0.898 |
| 7 | SRR25617833 | — | B | 0.891 |
| 8 | MNG499 | — | — | 0.887 |
| 9 | MNG763 | — | — | 0.882 |
| 10 | MNG599 | — | — | 0.880 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.300 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.290 | Cobimetinib | — uncovered |
| ALLOGRAFT_REJECTION | 0.280 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.270 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.140 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.140 | Inavolisib | — uncovered |
| MYOGENESIS | 0.120 | Inavolisib | — uncovered |
| COAGULATION | 0.080 | Binimetinib | — uncovered |