SRR1329551
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1444559 | GTEX | — | 0.928 |
| 2 | SRR1315145 | GTEX | — | 0.920 |
| 3 | BS_1ZVXF5FE | pilocytic astrocytoma | — | 0.918 |
| 4 | SRR1417202 | GTEX | — | 0.917 |
| 5 | SRR820292 | GTEX | — | 0.917 |
| 6 | SRR1331289 | GTEX | — | 0.917 |
| 7 | SRR819793 | GTEX | — | 0.916 |
| 8 | SRR817758 | GTEX | — | 0.916 |
| 9 | SRR1486863 | GTEX | — | 0.909 |
| 10 | SRR1332856 | GTEX | — | 0.909 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 19 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INFLAMMATORY_RESPONSE | 0.303 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.243 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.230 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.225 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.224 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.224 | Cobimetinib | — uncovered |
| BILE_ACID_METABOLISM | 0.216 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.204 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.194 | Temsirolimus | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.187 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.153 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.150 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.148 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.127 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.051 | Inavolisib | — uncovered |
| COAGULATION | 0.048 | Binimetinib | — uncovered |
| COMPLEMENT | 0.045 | Inavolisib | — uncovered |
| PEROXISOME | 0.036 | Idelalisib | — uncovered |
| ANGIOGENESIS | 0.035 | Remibrutinib | — uncovered |