Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR2779596

2d0cbc14-c4c5-55b5-aebf-eb7ff946644f

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V1+0.500
  • MYC_TARGETS_V2+0.400
  • OXIDATIVE_PHOSPHORYLATION+0.400
  • PROTEIN_SECRETION+0.400
  • UNFOLDED_PROTEIN_RESPONSE+0.400
  • PI3K_AKT_MTOR_SIGNALING+0.300
  • ANDROGEN_RESPONSE+0.200
  • DNA_REPAIR+0.200
  • MTORC1_SIGNALING+0.200
  • ADIPOGENESIS+0.100

Top 10 suppressed

  • ANGIOGENESIS-0.500
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
  • APICAL_SURFACE-0.400
  • INFLAMMATORY_RESPONSE-0.400
  • INTERFERON_GAMMA_RESPONSE-0.400
  • KRAS_SIGNALING_DN-0.400
  • KRAS_SIGNALING_UP-0.400
  • ALLOGRAFT_REJECTION-0.300
  • COAGULATION-0.300
  • ESTROGEN_RESPONSE_EARLY-0.300

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1s0112303
melanoma-umap@29
0.842
2BS_K74PZET7
medullo-epn-umap@date-based
MedMedulloblastoma0.838
3SJEPD003_D.RNA-Seq
medullo-epn-umap@date-based
EPNSupratentorial EPN0.829
4BS_JFB984RG
medullo-epn-umap@date-based
MedMedulloblastoma0.823
5SRR26320097
bladder-landscape@3
0.823
6R224
bladder-landscape@3
0.818
7SRR12202452
bladder-landscape@3
0.816
828541e4e-2e2b-4772-9566-acf35b31a581
melanoma-umap@29
0.816
9MDT-AP-3088
medullo-epn-umap@date-based
MedMedulloblastoma0.816
10MDT-AP-1353
medullo-epn-umap@date-based
MedMedulloblastoma0.809

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 15 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V10.500Inavolisib— uncovered
MYC_TARGETS_V20.400Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.400Remibrutinib— uncovered
PROTEIN_SECRETION0.400Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.400Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.300Inavolisib— uncovered
ANDROGEN_RESPONSE0.200Inavolisib— uncovered
DNA_REPAIR0.200Idelalisib— uncovered
MTORC1_SIGNALING0.200Inavolisib— uncovered
ADIPOGENESIS0.100Inavolisib— uncovered
FATTY_ACID_METABOLISM0.100Inavolisib— uncovered
HEDGEHOG_SIGNALING0.100Inavolisib— uncovered
HEME_METABOLISM0.100Temsirolimus— uncovered
P53_PATHWAY0.100Idelalisib— uncovered
UV_RESPONSE_DN0.100Inavolisib— uncovered