s0112303
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.600
- MYC_TARGETS_V1+0.500
- UNFOLDED_PROTEIN_RESPONSE+0.400
- OXIDATIVE_PHOSPHORYLATION+0.300
- ADIPOGENESIS+0.200
- DNA_REPAIR+0.200
- PROTEIN_SECRETION+0.200
- FATTY_ACID_METABOLISM+0.100
- ANDROGEN_RESPONSE+0.000
- BILE_ACID_METABOLISM+0.000
Top 10 suppressed
- APICAL_SURFACE-0.500
- INTERFERON_ALPHA_RESPONSE-0.500
- INTERFERON_GAMMA_RESPONSE-0.500
- ALLOGRAFT_REJECTION-0.400
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.400
- ANGIOGENESIS-0.300
- APICAL_JUNCTION-0.300
- CHOLESTEROL_HOMEOSTASIS-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | dfc53815-0784-48c7-84aa-f23d087a13df | — | — | 0.885 |
| 2 | 15d39440-6bb8-4ecb-add1-9ae8b007dc70 | — | — | 0.848 |
| 3 | s0095168 | — | — | 0.845 |
| 4 | R16 | — | — | 0.844 |
| 5 | SRR2779596 | — | — | 0.842 |
| 6 | SRR5088889 | — | — | 0.839 |
| 7 | SRR5088890 | — | — | 0.837 |
| 8 | BS_VJVDJABP | Embryonal tumors | — | 0.836 |
| 9 | GSM5359423 | — | — | 0.830 |
| 10 | SRR10900578 | — | — | 0.829 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.600 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.500 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.400 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.300 | Remibrutinib | — uncovered |
| ADIPOGENESIS | 0.200 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.200 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.200 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |