Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR1337412

GTEX

2d8f93ec-f11e-5625-a869-91b381e21cdb

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1341702
brain-umap@2
GTEX0.961
2SRR1383059
brain-umap@2
GTEX0.955
3BS_044XZ8ST
brain-umap@2
pilocytic astrocytoma0.945
4SRR1359171
brain-umap@2
GTEX0.945
5SRR1381757
brain-umap@2
GTEX0.935
6BS_4BWB0FA0
brain-umap@2
low-grade glioma0.933
7SRR1352954
brain-umap@2
GTEX0.928
8BS_3XY76V8T
brain-umap@2
Ganglioglioma0.926
9SRR1444622
brain-umap@2
GTEX0.923
10SRR1338923
brain-umap@2
GTEX0.917

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 35 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
TNFA_SIGNALING_VIA_NFKB0.513Inavolisib— uncovered
APICAL_SURFACE0.450Temsirolimus— uncovered
KRAS_SIGNALING_DN0.417Remibrutinib— uncovered
ANGIOGENESIS0.408Remibrutinib— uncovered
MYOGENESIS0.388Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.380Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.376Idelalisib— uncovered
APOPTOSIS0.336Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.332Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.326Inavolisib— uncovered
COAGULATION0.325Binimetinib— uncovered
ESTROGEN_RESPONSE_EARLY0.319Inavolisib— uncovered
P53_PATHWAY0.299Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.287Inavolisib— uncovered
FATTY_ACID_METABOLISM0.285Inavolisib— uncovered
KRAS_SIGNALING_UP0.278Inavolisib— uncovered
PANCREAS_BETA_CELLS0.273Cobimetinib— uncovered
BILE_ACID_METABOLISM0.272Inavolisib— uncovered
HYPOXIA0.258Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.253Remibrutinib— uncovered