C3L-00604
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 61.14989733
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- CHOLESTEROL_HOMEOSTASIS+0.300
- NOTCH_SIGNALING+0.250
- BILE_ACID_METABOLISM+0.180
- OXIDATIVE_PHOSPHORYLATION+0.170
- DNA_REPAIR+0.160
- PANCREAS_BETA_CELLS+0.160
- PEROXISOME+0.120
- HEME_METABOLISM+0.090
- FATTY_ACID_METABOLISM+0.080
- KRAS_SIGNALING_DN+0.000
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.450
- MYC_TARGETS_V2-0.420
- HYPOXIA-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- MYC_TARGETS_V1-0.380
- ALLOGRAFT_REJECTION-0.370
- INFLAMMATORY_RESPONSE-0.340
- INTERFERON_GAMMA_RESPONSE-0.340
- MTORC1_SIGNALING-0.330
- G2M_CHECKPOINT-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-37-4129-01A-01R-1100-07 | — | cohortSC | 0.840 |
| 2 | MNG512 | — | — | 0.827 |
| 3 | BS_67Z63A2K | EPN | Posterior Fossa EPN | 0.825 |
| 4 | TCGA-E2-A1B4-01A-11R-A12P-07 | — | B | 0.820 |
| 5 | SRR4296076 | — | cohortA1 | 0.806 |
| 6 | TCGA-BH-A0HN-01A-11R-A10U-07 | — | B | 0.805 |
| 7 | MNG199 | — | — | 0.804 |
| 8 | TCGA-55-8087-01A-11R-2241-07 | — | cohortA1 | 0.804 |
| 9 | SRR2700736 | — | — | 0.803 |
| 10 | MBCProject_0004_T1_RNA | — | C | 0.799 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| CHOLESTEROL_HOMEOSTASIS | 0.300 | Remibrutinib | — uncovered |
| NOTCH_SIGNALING | 0.250 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.180 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.170 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.160 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.160 | Cobimetinib | — uncovered |
| PEROXISOME | 0.120 | Idelalisib | — uncovered |
| HEME_METABOLISM | 0.090 | Temsirolimus | — uncovered |
| FATTY_ACID_METABOLISM | 0.080 | Inavolisib | — uncovered |