Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-E2-A1B4-01A-11R-A12P-07

· B

eeb1632e-1938-598e-a178-914b5dca2233

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
33

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.340
  • ESTROGEN_RESPONSE_EARLY+0.130
  • P53_PATHWAY+0.120
  • DNA_REPAIR+0.110
  • FATTY_ACID_METABOLISM+0.090
  • BILE_ACID_METABOLISM+0.060
  • ESTROGEN_RESPONSE_LATE+0.050
  • PEROXISOME+0.050
  • APICAL_SURFACE+0.040
  • ADIPOGENESIS+0.010

Top 10 suppressed

  • E2F_TARGETS-0.580
  • G2M_CHECKPOINT-0.580
  • ALLOGRAFT_REJECTION-0.510
  • INTERFERON_GAMMA_RESPONSE-0.500
  • IL6_JAK_STAT3_SIGNALING-0.430
  • INFLAMMATORY_RESPONSE-0.430
  • MITOTIC_SPINDLE-0.420
  • INTERFERON_ALPHA_RESPONSE-0.390
  • COMPLEMENT-0.370
  • MYC_TARGETS_V2-0.370

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-AC-A3TN-01A-11R-A22K-07
breast-umap@18
B0.912
2TCGA-CF-A5U8-01A-11R-A28M-07
bladder-landscape@3
0.890
3ERR2278853
head-neck@1
0.888
4TCGA-AO-A125-01A-11R-A10J-07
breast-umap@18
B0.885
5SJEPD001522_R1.RNA-Seq
medullo-epn-umap@date-based
EPNEPN Tumor0.879
6TCGA-YF-AA3L-01A-11R-A38B-07
bladder-landscape@3
0.879
7SRR6079984
head-neck@1
0.872
8SRR2016961
head-neck@1
0.872
9TCGA-BH-A0HN-01A-11R-A10U-07
breast-umap@18
B0.867
10308a5759-8930-433f-8d11-4c3da6ed0e29
colon-landscapes@1
0.861

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 11 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.340Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.130Inavolisib— uncovered
P53_PATHWAY0.120Idelalisib— uncovered
DNA_REPAIR0.110Idelalisib— uncovered
FATTY_ACID_METABOLISM0.090Inavolisib— uncovered
BILE_ACID_METABOLISM0.060Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.050Idelalisib— uncovered
PEROXISOME0.050Idelalisib— uncovered
APICAL_SURFACE0.040Temsirolimus— uncovered
ADIPOGENESIS0.010Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.010Inavolisib— uncovered