Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_YEQVW4ND

low-grade glioma

324611ea-5e6e-558d-81b6-ee4876f59beb

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
low-grade glioma
cancer_type_detailed
subtype
cancer_type
low-grade glioma
overall_survival_months
75.68988173455979
age_years
9.975
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1MDT-AP-2774
medullo-epn-umap@date-based
MedMedulloblastoma0.958
2MDT-AP-0385
medullo-epn-umap@date-based
MedMedulloblastoma0.945
3BS_52426AMF
brain-umap@2
low-grade glioma0.925
4MDT-AP-0226
medullo-epn-umap@date-based
MedMedulloblastoma0.923
5BS_M4TTKPNR
brain-umap@2
pilocytic astrocytoma0.918
6BS_55JW3HFM
brain-umap@2
Ganglioglioma0.913
7sclcM1201764A_S68.txt
lung-landscapes@6
cohortMD20.910
8BS_FJZPQZ2C
brain-umap@2
pleomorphic xanthoastrocytoma(PXA)0.908
9SRR8518208
breast-umap@18
D0.905
10BS_1TPWFSK6
brain-umap@2
subependymal giant cell astrocytoma(SEGA)0.904

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 42 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.458Remibrutinib— uncovered
ANGIOGENESIS0.403Remibrutinib— uncovered
ANDROGEN_RESPONSE0.393Inavolisib— uncovered
KRAS_SIGNALING_UP0.389Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.366Idelalisib— uncovered
COMPLEMENT0.358Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.357Inavolisib— uncovered
COAGULATION0.350Binimetinib— uncovered
MYOGENESIS0.336Inavolisib— uncovered
PANCREAS_BETA_CELLS0.333Cobimetinib— uncovered
IL2_STAT5_SIGNALING0.322Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.318Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.316Idelalisib— uncovered
APOPTOSIS0.313Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.312Inavolisib— uncovered
UV_RESPONSE_DN0.291Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.289Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.285Inavolisib— uncovered
ALLOGRAFT_REJECTION0.283Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.249Inavolisib— uncovered