MNG1248
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ALLOGRAFT_REJECTION+0.399
- INTERFERON_ALPHA_RESPONSE+0.381
- INTERFERON_GAMMA_RESPONSE+0.319
- KRAS_SIGNALING_DN+0.222
- IL6_JAK_STAT3_SIGNALING+0.191
- APICAL_SURFACE+0.032
- INFLAMMATORY_RESPONSE+0.028
- COMPLEMENT+0.024
- IL2_STAT5_SIGNALING-0.009
- SPERMATOGENESIS-0.016
Top 10 suppressed
- PROTEIN_SECRETION-0.566
- MYC_TARGETS_V1-0.530
- MTORC1_SIGNALING-0.479
- UNFOLDED_PROTEIN_RESPONSE-0.477
- OXIDATIVE_PHOSPHORYLATION-0.447
- ANDROGEN_RESPONSE-0.396
- ADIPOGENESIS-0.387
- UV_RESPONSE_DN-0.343
- G2M_CHECKPOINT-0.339
- NOTCH_SIGNALING-0.339
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG450 | — | — | 0.912 |
| 2 | MNG1098 | — | — | 0.912 |
| 3 | MNG882 | — | — | 0.906 |
| 4 | TCGA-ZF-A9R7-01A-11R-A38B-07 | — | — | 0.903 |
| 5 | TCGA-MN-A4N5-01A-11R-A24X-07 | — | cohortA1 | 0.901 |
| 6 | SRR12202481 | — | — | 0.899 |
| 7 | 362a2015-1791-4934-be81-df39540b38ff | — | — | 0.890 |
| 8 | SRR934910 | — | — | 0.889 |
| 9 | X65f5effa.07f7.4ed3.9e0a.3a0d9d451474 | — | cohortA1 | 0.883 |
| 10 | SRR650162 | — | — | 0.878 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ALLOGRAFT_REJECTION | 0.399 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.381 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.319 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.222 | Remibrutinib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.191 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.032 | Temsirolimus | — uncovered |
| INFLAMMATORY_RESPONSE | 0.028 | Idelalisib | — uncovered |
| COMPLEMENT | 0.024 | Inavolisib | — uncovered |