X65f5effa.07f7.4ed3.9e0a.3a0d9d451474
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 80
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.330
- ALLOGRAFT_REJECTION+0.320
- INTERFERON_GAMMA_RESPONSE+0.290
- MITOTIC_SPINDLE+0.140
- IL6_JAK_STAT3_SIGNALING+0.110
- COMPLEMENT+0.060
- IL2_STAT5_SIGNALING+0.060
- INFLAMMATORY_RESPONSE+0.060
- KRAS_SIGNALING_DN+0.030
- WNT_BETA_CATENIN_SIGNALING+0.030
Top 10 suppressed
- MYC_TARGETS_V1-0.580
- OXIDATIVE_PHOSPHORYLATION-0.560
- MTORC1_SIGNALING-0.550
- UNFOLDED_PROTEIN_RESPONSE-0.510
- PROTEIN_SECRETION-0.490
- CHOLESTEROL_HOMEOSTASIS-0.460
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.460
- MYC_TARGETS_V2-0.450
- TGF_BETA_SIGNALING-0.450
- E2F_TARGETS-0.440
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2208971 | — | — | 0.902 |
| 2 | s0122234 | — | — | 0.899 |
| 3 | ERR2208899 | — | — | 0.899 |
| 4 | TCGA-MN-A4N5-01A-11R-A24X-07 | — | cohortA1 | 0.898 |
| 5 | MNG882 | — | — | 0.893 |
| 6 | AUR-AFSP-TTP1-A-8-0-R-A741-41 | — | D | 0.893 |
| 7 | MNG1098 | — | — | 0.890 |
| 8 | AUR-AG0J-TTP1-A-1-0-R-A741-41 | — | D | 0.887 |
| 9 | bae6fdb5-9df3-433c-9a4c-e5c159a62bc6 | — | — | 0.887 |
| 10 | MNG1248 | — | — | 0.883 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.330 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.320 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.290 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.140 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.110 | Inavolisib | — uncovered |
| COMPLEMENT | 0.060 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.060 | Idelalisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.060 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.030 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.030 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.010 | Temsirolimus | — uncovered |