Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-GU-A763-01A-11R-A32O-07

36b58e9a-c770-59f7-a9e6-136a81b3fdba

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
32.75295664
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.560
  • MYC_TARGETS_V2+0.500
  • MYC_TARGETS_V1+0.330
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.310
  • DNA_REPAIR+0.210
  • FATTY_ACID_METABOLISM+0.210
  • ADIPOGENESIS+0.190
  • XENOBIOTIC_METABOLISM+0.180
  • KRAS_SIGNALING_DN+0.170
  • PANCREAS_BETA_CELLS+0.170

Top 10 suppressed

  • MITOTIC_SPINDLE-0.540
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.460
  • PROTEIN_SECRETION-0.460
  • G2M_CHECKPOINT-0.440
  • HEDGEHOG_SIGNALING-0.440
  • UV_RESPONSE_DN-0.440
  • INFLAMMATORY_RESPONSE-0.400
  • ANGIOGENESIS-0.390
  • IL6_JAK_STAT3_SIGNALING-0.370
  • TNFA_SIGNALING_VIA_NFKB-0.350

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-MT-A67A-01A-11R-A30B-07
head-neck@1
0.934
2TCGA-A2-A3XV-01A-21R-A239-07
breast-umap@18
B0.876
3MDT-AP-1302
medullo-epn-umap@date-based
MedMedulloblastoma0.875
4fa9f3cc6-06eb-4cfd-8f85-9d13df39d11e
melanoma-umap@29
0.866
579e77cb6-d567-4e9b-99df-e38e6e05d72e
melanoma-umap@29
0.863
6SRR1313092
breast-umap@18
B0.863
7TCGA-XF-AAN1-01A-31R-A42T-07
bladder-landscape@3
0.846
8SRR2016956
head-neck@1
0.844
9TCGA-LL-A6FP-01A-11R-A31O-07
breast-umap@18
B0.843
104245e942-3439-4e98-9733-b0b8ac25ad56
melanoma-umap@29
0.839

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 16 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.560Remibrutinib— uncovered
MYC_TARGETS_V20.500Idelalisib— uncovered
MYC_TARGETS_V10.330Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.310Inavolisib— uncovered
DNA_REPAIR0.210Idelalisib— uncovered
FATTY_ACID_METABOLISM0.210Inavolisib— uncovered
ADIPOGENESIS0.190Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.180Inavolisib— uncovered
KRAS_SIGNALING_DN0.170Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.170Cobimetinib— uncovered
PEROXISOME0.100Idelalisib— uncovered
BILE_ACID_METABOLISM0.090Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.090Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.070Idelalisib— uncovered
P53_PATHWAY0.040Idelalisib— uncovered
GLYCOLYSIS0.030Inavolisib— uncovered