fa9f3cc6-06eb-4cfd-8f85-9d13df39d11e
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-GU-A763-01A-11R-A32O-07 | — | — | 0.866 |
| 2 | TCGA-MT-A67A-01A-11R-A30B-07 | — | — | 0.845 |
| 3 | SRR5088856 | — | — | 0.833 |
| 4 | 79e77cb6-d567-4e9b-99df-e38e6e05d72e | — | — | 0.807 |
| 5 | SRR2016956 | — | — | 0.802 |
| 6 | MDT-AP-1302 | Med | Medulloblastoma | 0.800 |
| 7 | SRR10900578 | — | — | 0.800 |
| 8 | C3N-01071 | — | cohortA4 | 0.796 |
| 9 | TCGA-D6-A74Q-01A-11R-A34R-07 | — | — | 0.790 |
| 10 | BS_TNRHHYNC | Spinal Cord Ependymoma | — | 0.789 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.500 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.400 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.300 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.200 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.200 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.100 | Remibrutinib | — uncovered |
| GLYCOLYSIS | 0.100 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.100 | Remibrutinib | — uncovered |
| P53_PATHWAY | 0.100 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.100 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.100 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.100 | Idelalisib | — uncovered |