Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_ZZPBANDD

DNET

36e61c56-8777-511e-98b0-1eeb1a15c687

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
DNET
cancer_type_detailed
subtype
cancer_type
DNET
age_years
11.066
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.526
  • NOTCH_SIGNALING+0.372
  • ADIPOGENESIS+0.313
  • FATTY_ACID_METABOLISM+0.281
  • KRAS_SIGNALING_DN+0.280
  • HEDGEHOG_SIGNALING+0.278
  • APICAL_SURFACE+0.252
  • PANCREAS_BETA_CELLS+0.242
  • ESTROGEN_RESPONSE_EARLY+0.215
  • MYOGENESIS+0.207

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.421
  • E2F_TARGETS-0.368
  • MYC_TARGETS_V1-0.356
  • IL6_JAK_STAT3_SIGNALING-0.352
  • UNFOLDED_PROTEIN_RESPONSE-0.310
  • INTERFERON_GAMMA_RESPONSE-0.307
  • G2M_CHECKPOINT-0.290
  • DNA_REPAIR-0.278
  • IL2_STAT5_SIGNALING-0.242
  • INFLAMMATORY_RESPONSE-0.214

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_AD4JPN9Q
brain-umap@2
Ganglioglioma0.847
2SRR1418837
brain-umap@2
GTEX0.832
3BS_KZPR01BD
brain-umap@2
DNET0.806
4BS_VMMJYN8Z
brain-umap@2
Ganglioglioma0.803
5BS_E4QK839R
brain-umap@2
low-grade glioma0.800
6GSM6454744
breast-umap@18
A0.798
7BS_CVGFNCBJ
brain-umap@2
low-grade glioma0.798
8BS_CGB2WS2A
brain-umap@2
pilocytic astrocytoma0.788
9SRR818418
brain-umap@2
GTEX0.784
10SRR1457482
brain-umap@2
GTEX0.782

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 21 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.526Remibrutinib— uncovered
NOTCH_SIGNALING0.372Inavolisib— uncovered
ADIPOGENESIS0.313Inavolisib— uncovered
FATTY_ACID_METABOLISM0.281Inavolisib— uncovered
KRAS_SIGNALING_DN0.280Remibrutinib— uncovered
HEDGEHOG_SIGNALING0.278Inavolisib— uncovered
APICAL_SURFACE0.252Temsirolimus— uncovered
PANCREAS_BETA_CELLS0.242Cobimetinib— uncovered
ESTROGEN_RESPONSE_EARLY0.215Inavolisib— uncovered
MYOGENESIS0.207Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.201Idelalisib— uncovered
BILE_ACID_METABOLISM0.182Inavolisib— uncovered
PEROXISOME0.141Idelalisib— uncovered
SPERMATOGENESIS0.127Inavolisib— uncovered
UV_RESPONSE_UP0.127Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.120Inavolisib— uncovered
APICAL_JUNCTION0.096Inavolisib— uncovered
UV_RESPONSE_DN0.057Inavolisib— uncovered
HEME_METABOLISM0.056Temsirolimus— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.039Inavolisib— uncovered