SRR821468
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V1+0.335
- OXIDATIVE_PHOSPHORYLATION+0.270
- DNA_REPAIR+0.249
- UNFOLDED_PROTEIN_RESPONSE+0.223
- PI3K_AKT_MTOR_SIGNALING+0.219
- PROTEIN_SECRETION+0.175
- MTORC1_SIGNALING+0.123
- MYC_TARGETS_V2+0.123
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.122
- HEME_METABOLISM+0.077
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.553
- INTERFERON_GAMMA_RESPONSE-0.445
- INFLAMMATORY_RESPONSE-0.409
- NOTCH_SIGNALING-0.381
- TNFA_SIGNALING_VIA_NFKB-0.351
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.346
- IL6_JAK_STAT3_SIGNALING-0.334
- ALLOGRAFT_REJECTION-0.329
- TGF_BETA_SIGNALING-0.329
- IL2_STAT5_SIGNALING-0.295
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR818188 | GTEX | — | 0.940 |
| 2 | SRR1477773 | GTEX | — | 0.936 |
| 3 | SRR1467364 | GTEX | — | 0.934 |
| 4 | SRR1407560 | GTEX | — | 0.932 |
| 5 | SRR1316874 | GTEX | — | 0.925 |
| 6 | SRR604098 | GTEX | — | 0.925 |
| 7 | SRR1403915 | GTEX | — | 0.925 |
| 8 | SRR1327975 | GTEX | — | 0.921 |
| 9 | SRR1432321 | GTEX | — | 0.918 |
| 10 | SRR1394677 | GTEX | — | 0.916 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 16 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V1 | 0.335 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.270 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.249 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.223 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.219 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.175 | Remibrutinib | — uncovered |
| MTORC1_SIGNALING | 0.123 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.123 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.122 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.077 | Temsirolimus | — uncovered |
| UV_RESPONSE_UP | 0.065 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.062 | Inavolisib | — uncovered |
| PEROXISOME | 0.034 | Idelalisib | — uncovered |
| MYOGENESIS | 0.028 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.019 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.018 | Inavolisib | — uncovered |