SRR33346960
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.630
- G2M_CHECKPOINT+0.600
- MYC_TARGETS_V1+0.580
- MYC_TARGETS_V2+0.560
- UNFOLDED_PROTEIN_RESPONSE+0.420
- MITOTIC_SPINDLE+0.290
- SPERMATOGENESIS+0.230
- DNA_REPAIR+0.160
- MTORC1_SIGNALING+0.140
- TGF_BETA_SIGNALING+0.060
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.600
- INTERFERON_GAMMA_RESPONSE-0.460
- KRAS_SIGNALING_UP-0.370
- TNFA_SIGNALING_VIA_NFKB-0.370
- INFLAMMATORY_RESPONSE-0.340
- IL6_JAK_STAT3_SIGNALING-0.310
- COAGULATION-0.290
- FATTY_ACID_METABOLISM-0.280
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.270
- COMPLEMENT-0.260
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR10900561 | — | — | 0.911 |
| 2 | SAMN03290940 | — | — | 0.908 |
| 3 | BS_N6N147BY | Embryonal tumors | — | 0.904 |
| 4 | AUR-AG0N-TTM1-A-1-1-R-A743-41 | — | E | 0.904 |
| 5 | BS_HE57E1RP | medulloblastoma | — | 0.903 |
| 6 | TCGA-A1-A0SO-01A-22R-A084-07 | — | E | 0.903 |
| 7 | MNG704 | — | — | 0.903 |
| 8 | SRR12696755 | — | — | 0.902 |
| 9 | BS_M4923M40 | ATRT | — | 0.901 |
| 10 | TCGA-AC-A2BK-01A-11R-A21T-07 | — | E | 0.899 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.630 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.600 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.580 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.560 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.420 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.290 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.230 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.160 | Idelalisib | — uncovered |
| MTORC1_SIGNALING | 0.140 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.060 | Inavolisib | — uncovered |