SAMN03290940
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.600
- MYC_TARGETS_V1+0.600
- MYC_TARGETS_V2+0.600
- G2M_CHECKPOINT+0.500
- UNFOLDED_PROTEIN_RESPONSE+0.400
- MITOTIC_SPINDLE+0.300
- DNA_REPAIR+0.200
- OXIDATIVE_PHOSPHORYLATION+0.100
- PEROXISOME+0.100
- SPERMATOGENESIS+0.100
Top 10 suppressed
- COAGULATION-0.500
- INTERFERON_ALPHA_RESPONSE-0.500
- APICAL_SURFACE-0.400
- COMPLEMENT-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.400
- INTERFERON_GAMMA_RESPONSE-0.400
- TNFA_SIGNALING_VIA_NFKB-0.400
- XENOBIOTIC_METABOLISM-0.400
- ALLOGRAFT_REJECTION-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SAMN03290927 | — | — | 0.958 |
| 2 | SRR5088887 | — | — | 0.943 |
| 3 | BS_N6N147BY | Embryonal tumors | — | 0.938 |
| 4 | SRR13780247 | — | cohortMD1 | 0.924 |
| 5 | BS_5P1TN10Z | Embryonal tumors | — | 0.924 |
| 6 | SRR10900561 | — | — | 0.920 |
| 7 | TCGA-78-7155-01A-11R-2039-07 | — | cohortMD1 | 0.920 |
| 8 | BS_TV5B86ZD | Embryonal tumors | — | 0.919 |
| 9 | 2B4FA61A-C1A7-49BD-9438-2865D386EAF2 | — | — | 0.919 |
| 10 | BS_K25F4J3V | ATRT | — | 0.919 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.600 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.600 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.600 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.500 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.400 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.300 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.200 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.100 | Remibrutinib | — uncovered |
| PEROXISOME | 0.100 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.100 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.100 | Inavolisib | — uncovered |