SRR13311176
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.370
- WNT_BETA_CATENIN_SIGNALING+0.280
- MITOTIC_SPINDLE+0.220
- KRAS_SIGNALING_DN+0.200
- MYOGENESIS+0.180
- SPERMATOGENESIS+0.140
- APICAL_JUNCTION+0.110
- TGF_BETA_SIGNALING+0.050
- TNFA_SIGNALING_VIA_NFKB+0.030
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.020
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.650
- MYC_TARGETS_V1-0.620
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.500
- MTORC1_SIGNALING-0.490
- PROTEIN_SECRETION-0.480
- UNFOLDED_PROTEIN_RESPONSE-0.480
- ADIPOGENESIS-0.450
- MYC_TARGETS_V2-0.440
- FATTY_ACID_METABOLISM-0.430
- CHOLESTEROL_HOMEOSTASIS-0.410
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR4195662 | — | — | 0.896 |
| 2 | SRR29022832 | — | A | 0.887 |
| 3 | MBCProject_2661_T2_RNA | — | A | 0.883 |
| 4 | BS_YK6VQ9SJ | DNET | — | 0.883 |
| 5 | SRR6013520 | — | cohortA1 | 0.877 |
| 6 | TCGA-A7-A26I-01B-06R-A22O-07 | — | D | 0.876 |
| 7 | BS_9CA93S6D | Diffuse intrinsic pontine glioma | — | 0.875 |
| 8 | a83e78c0-8b1b-4576-aace-4bee1dee5046 | — | — | 0.874 |
| 9 | d2995480-5ae0-42e1-9a21-25e1435201ee | — | — | 0.872 |
| 10 | MNG790 | — | — | 0.867 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.370 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.280 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.220 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.200 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.180 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.140 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.110 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.050 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.030 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.020 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.010 | Inavolisib | — uncovered |