SRR6013520
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.190
- MITOTIC_SPINDLE+0.120
- UV_RESPONSE_DN+0.040
- APICAL_SURFACE+0.010
- MYOGENESIS+0.000
- SPERMATOGENESIS+0.000
- KRAS_SIGNALING_UP-0.030
- BILE_ACID_METABOLISM-0.040
- HEDGEHOG_SIGNALING-0.040
- PANCREAS_BETA_CELLS-0.040
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.630
- MYC_TARGETS_V1-0.600
- MTORC1_SIGNALING-0.510
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.510
- UNFOLDED_PROTEIN_RESPONSE-0.470
- E2F_TARGETS-0.450
- GLYCOLYSIS-0.420
- PROTEIN_SECRETION-0.410
- G2M_CHECKPOINT-0.370
- ADIPOGENESIS-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR11296737 | — | — | 0.924 |
| 2 | SRR1516040 | — | — | 0.921 |
| 3 | TCGA-CU-A3YL-01A-11R-A22U-07 | — | — | 0.916 |
| 4 | SRR934787 | — | — | 0.912 |
| 5 | ERR4976613 | — | D | 0.904 |
| 6 | BS_4GTESTSE | Ganglioglioma | — | 0.903 |
| 7 | MNG1217 | — | — | 0.903 |
| 8 | BS_YNEQJ6AH | DNET | — | 0.901 |
| 9 | MNG786 | — | — | 0.899 |
| 10 | 20040121.LumB | — | D | 0.899 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.190 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.120 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.040 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.010 | Temsirolimus | — uncovered |