Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934916

39dd2462-167e-5c7d-ac4d-314f343e5c8a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
25.36136662286465
age_years
51
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PANCREAS_BETA_CELLS+0.338
  • ALLOGRAFT_REJECTION+0.310
  • ANGIOGENESIS+0.265
  • INTERFERON_ALPHA_RESPONSE+0.212
  • INTERFERON_GAMMA_RESPONSE+0.202
  • COAGULATION+0.178
  • IL6_JAK_STAT3_SIGNALING+0.178
  • KRAS_SIGNALING_DN+0.148
  • KRAS_SIGNALING_UP+0.137
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.132

Top 10 suppressed

  • CHOLESTEROL_HOMEOSTASIS-0.463
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.422
  • MITOTIC_SPINDLE-0.418
  • MTORC1_SIGNALING-0.403
  • MYC_TARGETS_V1-0.393
  • OXIDATIVE_PHOSPHORYLATION-0.392
  • ANDROGEN_RESPONSE-0.383
  • MYC_TARGETS_V2-0.363
  • UNFOLDED_PROTEIN_RESPONSE-0.361
  • HEDGEHOG_SIGNALING-0.348

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1TCGA-91-A4BC-01A-11R-A24H-07
lung-landscapes@6
cohortA30.924
2SRR934910
brain-umap@2
0.918
3SRR8942994
bladder-landscape@3
0.899
4MNG882
mng-umap@100
0.894
5SRR1341057
brain-umap@2
GTEX0.893
6SRR1355373
brain-umap@2
GTEX0.882
7MNG1142
mng-umap@100
0.879
8SRR1413454
brain-umap@2
GTEX0.878
9SRR1358689
brain-umap@2
GTEX0.878
10EPT0776
medullo-epn-umap@date-based
EPNEPN Tumor0.877

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 16 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.338Cobimetinib— uncovered
ALLOGRAFT_REJECTION0.310Idelalisib— uncovered
ANGIOGENESIS0.265Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.212Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.202Idelalisib— uncovered
COAGULATION0.178Binimetinib— uncovered
IL6_JAK_STAT3_SIGNALING0.178Inavolisib— uncovered
KRAS_SIGNALING_DN0.148Remibrutinib— uncovered
KRAS_SIGNALING_UP0.137Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.132Inavolisib— uncovered
SPERMATOGENESIS0.106Inavolisib— uncovered
IL2_STAT5_SIGNALING0.040Idelalisib— uncovered
COMPLEMENT0.036Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.035Idelalisib— uncovered
BILE_ACID_METABOLISM0.024Inavolisib— uncovered
APICAL_SURFACE0.009Temsirolimus— uncovered