SRR8942994
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.500
- KRAS_SIGNALING_DN+0.430
- SPERMATOGENESIS+0.310
- ALLOGRAFT_REJECTION+0.270
- INFLAMMATORY_RESPONSE+0.190
- INTERFERON_GAMMA_RESPONSE+0.180
- INTERFERON_ALPHA_RESPONSE+0.150
- KRAS_SIGNALING_UP+0.140
- COAGULATION+0.120
- APICAL_SURFACE+0.100
Top 10 suppressed
- MYC_TARGETS_V1-0.590
- MYC_TARGETS_V2-0.580
- OXIDATIVE_PHOSPHORYLATION-0.570
- MITOTIC_SPINDLE-0.550
- UNFOLDED_PROTEIN_RESPONSE-0.550
- WNT_BETA_CATENIN_SIGNALING-0.550
- DNA_REPAIR-0.530
- TGF_BETA_SIGNALING-0.510
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.470
- P53_PATHWAY-0.460
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1413454 | GTEX | — | 0.946 |
| 2 | MNG1142 | — | — | 0.946 |
| 3 | SRR1313642 | GTEX | — | 0.941 |
| 4 | EPT0776 | EPN | EPN Tumor | 0.935 |
| 5 | MDT-AP-1143 | Med | Medulloblastoma | 0.934 |
| 6 | MNG436 | — | — | 0.933 |
| 7 | SRR12202406 | — | — | 0.933 |
| 8 | MNG1126 | — | — | 0.930 |
| 9 | MNG882 | — | — | 0.929 |
| 10 | MNG1148 | — | — | 0.928 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.500 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.430 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.310 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.270 | Idelalisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.190 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.180 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.150 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.140 | Inavolisib | — uncovered |
| COAGULATION | 0.120 | Binimetinib | — uncovered |
| APICAL_SURFACE | 0.100 | Temsirolimus | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.040 | Inavolisib | — uncovered |