SRR1405224
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- DNA_REPAIR+0.210
- OXIDATIVE_PHOSPHORYLATION+0.191
- PROTEIN_SECRETION+0.178
- KRAS_SIGNALING_DN+0.128
- SPERMATOGENESIS+0.108
- MYC_TARGETS_V2+0.065
- MYC_TARGETS_V1+0.041
- UNFOLDED_PROTEIN_RESPONSE+0.031
- PEROXISOME+0.016
- PI3K_AKT_MTOR_SIGNALING+0.007
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.640
- INTERFERON_GAMMA_RESPONSE-0.554
- INFLAMMATORY_RESPONSE-0.546
- ANGIOGENESIS-0.531
- IL6_JAK_STAT3_SIGNALING-0.531
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.518
- TNFA_SIGNALING_VIA_NFKB-0.513
- ALLOGRAFT_REJECTION-0.491
- COAGULATION-0.490
- APOPTOSIS-0.413
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1374246 | GTEX | — | 0.988 |
| 2 | SRR1500537 | GTEX | — | 0.988 |
| 3 | SRR1363810 | GTEX | — | 0.983 |
| 4 | SRR1393068 | GTEX | — | 0.983 |
| 5 | SRR1451897 | GTEX | — | 0.982 |
| 6 | SRR1441118 | GTEX | — | 0.982 |
| 7 | SRR1406917 | GTEX | — | 0.980 |
| 8 | SRR1421140 | GTEX | — | 0.980 |
| 9 | SRR1498702 | GTEX | — | 0.980 |
| 10 | SRR1394450 | GTEX | — | 0.980 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| DNA_REPAIR | 0.210 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.191 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.178 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.128 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.108 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.065 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.041 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.031 | Idelalisib | — uncovered |
| PEROXISOME | 0.016 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.007 | Inavolisib | — uncovered |