Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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SRR10900593

3aa8cb70-9af5-53a6-8ae5-9b011de58065

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PANCREAS_BETA_CELLS+0.400
  • SPERMATOGENESIS+0.400
  • KRAS_SIGNALING_DN+0.300
  • BILE_ACID_METABOLISM+0.200
  • COMPLEMENT+0.100
  • ALLOGRAFT_REJECTION+0.000
  • COAGULATION+0.000
  • KRAS_SIGNALING_UP+0.000
  • APICAL_SURFACE-0.100
  • INFLAMMATORY_RESPONSE-0.100

Top 10 suppressed

  • MYC_TARGETS_V2-0.500
  • NOTCH_SIGNALING-0.500
  • OXIDATIVE_PHOSPHORYLATION-0.500
  • ADIPOGENESIS-0.400
  • CHOLESTEROL_HOMEOSTASIS-0.400
  • DNA_REPAIR-0.400
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
  • GLYCOLYSIS-0.400
  • MYC_TARGETS_V1-0.400
  • P53_PATHWAY-0.400

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ERR4976608
breast-umap@18
D0.932
2SRR13311179
bladder-landscape@3
0.930
3SRR934779
brain-umap@2
0.928
4SRR8942981
bladder-landscape@3
0.925
5SRR12696761
melanoma-umap@29
0.923
6SRR934844
brain-umap@2
0.920
7SRR934856
brain-umap@2
0.919
8SRR26320083
bladder-landscape@3
0.918
9SRR33346946
bladder-landscape@3
0.914
10MNG597
mng-umap@100
0.913

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 5 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.400Cobimetinib— uncovered
SPERMATOGENESIS0.400Inavolisib— uncovered
KRAS_SIGNALING_DN0.300Remibrutinib— uncovered
BILE_ACID_METABOLISM0.200Inavolisib— uncovered
COMPLEMENT0.100Inavolisib— uncovered