Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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SRR26320083

3dc8e391-d343-5a32-a6ca-2edd6e8e41b8

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • SPERMATOGENESIS+0.430
  • PANCREAS_BETA_CELLS+0.400
  • KRAS_SIGNALING_DN+0.230
  • BILE_ACID_METABOLISM+0.080
  • E2F_TARGETS-0.170
  • INFLAMMATORY_RESPONSE-0.190
  • ALLOGRAFT_REJECTION-0.200
  • HEDGEHOG_SIGNALING-0.230
  • KRAS_SIGNALING_UP-0.240
  • COAGULATION-0.270

Top 10 suppressed

  • MYC_TARGETS_V1-0.570
  • PROTEIN_SECRETION-0.540
  • TGF_BETA_SIGNALING-0.540
  • INTERFERON_ALPHA_RESPONSE-0.530
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.520
  • APOPTOSIS-0.500
  • UNFOLDED_PROTEIN_RESPONSE-0.500
  • INTERFERON_GAMMA_RESPONSE-0.480
  • NOTCH_SIGNALING-0.480
  • ANDROGEN_RESPONSE-0.470

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR26320081
bladder-landscape@3
0.974
2SRR13311179
bladder-landscape@3
0.973
3ERR4976608
breast-umap@18
D0.967
4SRR8943038
bladder-landscape@3
0.963
5ERR4976605
breast-umap@18
D0.960
6SRR11296798
colon-landscapes@1
0.959
7SRR8942981
bladder-landscape@3
0.953
8SRR4195666
colon-landscapes@1
0.952
9SRR12202440
bladder-landscape@3
0.952
10c7d31245-5d71-4a23-8a33-4f83c4718e20
melanoma-umap@29
0.952

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
SPERMATOGENESIS0.430Inavolisib— uncovered
PANCREAS_BETA_CELLS0.400Cobimetinib— uncovered
KRAS_SIGNALING_DN0.230Remibrutinib— uncovered
BILE_ACID_METABOLISM0.080Inavolisib— uncovered