TCGA-4Z-AA7R-01A-11R-A39I-07
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- overall_survival_months
- 17.14848883
- os_event
- true
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.400
- SPERMATOGENESIS+0.320
- G2M_CHECKPOINT+0.300
- MITOTIC_SPINDLE+0.230
- FATTY_ACID_METABOLISM+0.160
- BILE_ACID_METABOLISM+0.110
- MTORC1_SIGNALING+0.110
- GLYCOLYSIS+0.040
- PEROXISOME+0.020
- KRAS_SIGNALING_DN+0.010
Top 10 suppressed
- INTERFERON_GAMMA_RESPONSE-0.520
- ALLOGRAFT_REJECTION-0.510
- INTERFERON_ALPHA_RESPONSE-0.500
- IL6_JAK_STAT3_SIGNALING-0.480
- INFLAMMATORY_RESPONSE-0.420
- P53_PATHWAY-0.400
- COMPLEMENT-0.370
- NOTCH_SIGNALING-0.370
- TNFA_SIGNALING_VIA_NFKB-0.350
- TGF_BETA_SIGNALING-0.340
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12202476 | — | — | 0.890 |
| 2 | SRR1516068 | — | — | 0.871 |
| 3 | SRR650147 | — | — | 0.868 |
| 4 | TCGA-GU-A42P-01A-11R-A23W-07 | — | — | 0.865 |
| 5 | SRR8943043 | — | — | 0.865 |
| 6 | MNG894 | — | — | 0.864 |
| 7 | R158 | — | — | 0.861 |
| 8 | TCGA-GV-A3JW-01A-11R-A20F-07 | — | — | 0.859 |
| 9 | TCGA-FD-A3SJ-01A-12R-A22U-07 | — | — | 0.851 |
| 10 | SRR8518343 | — | E | 0.850 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.400 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.320 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.300 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.230 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.160 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.110 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.110 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.040 | Inavolisib | — uncovered |
| PEROXISOME | 0.020 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.010 | Remibrutinib | — uncovered |