SRR6013576
— · cohortMD1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortMD1
- subtype
- cohortMD1
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-E2-A15S-01A-11R-A115-07 | — | B | 0.841 |
| 2 | TCGA-E2-A15R-01A-11R-A115-07 | — | B | 0.838 |
| 3 | TCGA-BH-A0HL-01A-11R-A10U-07 | — | B | 0.827 |
| 4 | MNG673 | — | — | 0.825 |
| 5 | SRR13780268 | — | cohortSC | 0.823 |
| 6 | SRR1797228 | — | cohortSC | 0.819 |
| 7 | TCGA-56-8083-01A-11R-2247-07 | — | cohortMD1 | 0.816 |
| 8 | SRR8518262 | — | E | 0.815 |
| 9 | MNG239 | — | — | 0.814 |
| 10 | 0D8C7EC1-9BFB-44A1-8AF8-05D2A6BBE0F9 | — | — | 0.814 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 16 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.440 | Cobimetinib | — uncovered |
| TGF_BETA_SIGNALING | 0.310 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.270 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.200 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.170 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.160 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.120 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.110 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.090 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.090 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.070 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.070 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.040 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.040 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.030 | Remibrutinib | — uncovered |
| ADIPOGENESIS | 0.010 | Inavolisib | — uncovered |