Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · head-neck@1

SRR25043613

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3d37803b-5f7c-5c0c-b7e7-a29c87697c02

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
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GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PANCREAS_BETA_CELLS+0.380
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.320
  • FATTY_ACID_METABOLISM+0.300
  • XENOBIOTIC_METABOLISM+0.280
  • COAGULATION+0.260
  • OXIDATIVE_PHOSPHORYLATION+0.250
  • DNA_REPAIR+0.240
  • ADIPOGENESIS+0.230
  • ANGIOGENESIS+0.230
  • KRAS_SIGNALING_DN+0.220

Top 10 suppressed

  • PROTEIN_SECRETION-0.470
  • G2M_CHECKPOINT-0.450
  • MITOTIC_SPINDLE-0.440
  • ANDROGEN_RESPONSE-0.340
  • E2F_TARGETS-0.340
  • MTORC1_SIGNALING-0.300
  • TNFA_SIGNALING_VIA_NFKB-0.300
  • UV_RESPONSE_DN-0.290
  • TGF_BETA_SIGNALING-0.260
  • SPERMATOGENESIS-0.210

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1MNG482
mng-umap@100
——0.806
29c8140ab-454c-4f62-aa6e-d1cfe4e498e0
colon-landscapes@1
——0.798
3MDT-AP-0720
medullo-epn-umap@date-based
MedMedulloblastoma0.798
4SRR1433600
brain-umap@2
GTEX—0.795
5TCGA-AC-A3QP-01A-11R-A22U-07
breast-umap@18
—B0.779
6SRR23303751
bladder-landscape@3
——0.776
7DRR168584
bladder-landscape@3
——0.775
8b83a1cf6-50a6-44fa-834d-8b3df88149fa
colon-landscapes@1
——0.774
9f693948b-2640-4fb5-b874-ec756465b5b3
colon-landscapes@1
——0.773
10SJEPD039_D.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.773

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.380Cobimetinib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.320Inavolisib— uncovered
FATTY_ACID_METABOLISM0.300Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.280Inavolisib— uncovered
COAGULATION0.260Binimetinib— uncovered
OXIDATIVE_PHOSPHORYLATION0.250Remibrutinib— uncovered
DNA_REPAIR0.240Idelalisib— uncovered
ADIPOGENESIS0.230Inavolisib— uncovered
ANGIOGENESIS0.230Remibrutinib— uncovered
KRAS_SIGNALING_DN0.220Remibrutinib— uncovered
WNT_BETA_CATENIN_SIGNALING0.210Inavolisib— uncovered
APICAL_JUNCTION0.170Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.170Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.170Inavolisib— uncovered
PEROXISOME0.160Idelalisib— uncovered
BILE_ACID_METABOLISM0.130Inavolisib— uncovered
ALLOGRAFT_REJECTION0.120Idelalisib— uncovered
IL2_STAT5_SIGNALING0.120Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.110Inavolisib— uncovered
MYOGENESIS0.110Inavolisib— uncovered