Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · brain-umap@2

SRR1433600

GTEX

77988c2f-f5af-59fb-9cf7-406d03496229

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
—
subtype
—
cancer_type
GTEX
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.355
  • OXIDATIVE_PHOSPHORYLATION+0.331
  • COAGULATION+0.287
  • APICAL_SURFACE+0.278
  • XENOBIOTIC_METABOLISM+0.274
  • INTERFERON_ALPHA_RESPONSE+0.267
  • KRAS_SIGNALING_DN+0.251
  • PEROXISOME+0.239
  • FATTY_ACID_METABOLISM+0.224
  • IL2_STAT5_SIGNALING+0.200

Top 10 suppressed

  • G2M_CHECKPOINT-0.388
  • UV_RESPONSE_DN-0.359
  • PROTEIN_SECRETION-0.353
  • UNFOLDED_PROTEIN_RESPONSE-0.341
  • E2F_TARGETS-0.321
  • TGF_BETA_SIGNALING-0.317
  • MITOTIC_SPINDLE-0.314
  • TNFA_SIGNALING_VIA_NFKB-0.274
  • HEDGEHOG_SIGNALING-0.213
  • MTORC1_SIGNALING-0.207

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1080172
brain-umap@2
GTEX—0.850
2SRR1419148
brain-umap@2
GTEX—0.846
3MDT-AP-0720
medullo-epn-umap@date-based
MedMedulloblastoma0.846
4SAMN03290901
melanoma-umap@29
——0.834
5ERR2598280
medullo-epn-umap@date-based
fetalfetal0.830
6TCGA-50-6597-01A-11R-1858-07
lung-landscapes@6
—cohortA10.818
7ERR2598328
medullo-epn-umap@date-based
fetalfetal0.818
8SRR1436106
brain-umap@2
GTEX—0.811
9ERR2598335
medullo-epn-umap@date-based
fetalfetal0.810
10SRR1399092
brain-umap@2
GTEX—0.805

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
REACTIVE_OXYGEN_SPECIES_PATHWAY0.355Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.331Remibrutinib— uncovered
COAGULATION0.287Binimetinib— uncovered
APICAL_SURFACE0.278Temsirolimus— uncovered
XENOBIOTIC_METABOLISM0.274Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.267Inavolisib— uncovered
KRAS_SIGNALING_DN0.251Remibrutinib— uncovered
PEROXISOME0.239Idelalisib— uncovered
FATTY_ACID_METABOLISM0.224Inavolisib— uncovered
IL2_STAT5_SIGNALING0.200Idelalisib— uncovered
BILE_ACID_METABOLISM0.196Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.186Idelalisib— uncovered
MYOGENESIS0.176Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.175Idelalisib— uncovered
ADIPOGENESIS0.158Inavolisib— uncovered
ANGIOGENESIS0.107Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.101Inavolisib— uncovered
SPERMATOGENESIS0.088Inavolisib— uncovered
ALLOGRAFT_REJECTION0.067Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.066Inavolisib— uncovered