Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR12202415

3d52b2c2-c895-56d3-94cf-0a1b5f95268d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8613736
breast-umap@18
E0.880
2ERR2598229
medullo-epn-umap@date-based
fetalfetal0.879
320120209.TNBC
breast-umap@18
E0.878
4TCGA-O2-A5IB-01A-11R-A27Q-07
lung-landscapes@6
cohortMD10.873
5TCGA-33-4587-01A-11R-2125-07
lung-landscapes@6
cohortMD10.872
6ERR2598195
medullo-epn-umap@date-based
fetalfetal0.869
7TCGA-50-6591-01A-11R-1755-07
lung-landscapes@6
cohortMD10.868
8MNG1194
mng-umap@100
0.866
9ERR2598238
medullo-epn-umap@date-based
fetalfetal0.865
10ERR2598206
medullo-epn-umap@date-based
fetalfetal0.864

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 20 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.320Inavolisib— uncovered
G2M_CHECKPOINT0.320Inavolisib— uncovered
MYC_TARGETS_V20.280Idelalisib— uncovered
MYC_TARGETS_V10.230Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.220Inavolisib— uncovered
NOTCH_SIGNALING0.200Inavolisib— uncovered
MITOTIC_SPINDLE0.190Inavolisib— uncovered
PROTEIN_SECRETION0.180Remibrutinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.170Inavolisib— uncovered
SPERMATOGENESIS0.130Inavolisib— uncovered
MTORC1_SIGNALING0.110Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.090Idelalisib— uncovered
GLYCOLYSIS0.080Inavolisib— uncovered
PEROXISOME0.070Idelalisib— uncovered
UV_RESPONSE_UP0.070Idelalisib— uncovered
HEDGEHOG_SIGNALING0.050Inavolisib— uncovered
TGF_BETA_SIGNALING0.030Inavolisib— uncovered
DNA_REPAIR0.020Idelalisib— uncovered
HEME_METABOLISM0.020Temsirolimus— uncovered
MYOGENESIS0.010Inavolisib— uncovered