SRR8943038
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.420
- SPERMATOGENESIS+0.330
- KRAS_SIGNALING_DN+0.240
- BILE_ACID_METABOLISM+0.170
- XENOBIOTIC_METABOLISM-0.040
- PEROXISOME-0.080
- FATTY_ACID_METABOLISM-0.140
- MYOGENESIS-0.150
- HEME_METABOLISM-0.190
- COAGULATION-0.220
Top 10 suppressed
- TGF_BETA_SIGNALING-0.590
- NOTCH_SIGNALING-0.580
- INTERFERON_GAMMA_RESPONSE-0.510
- TNFA_SIGNALING_VIA_NFKB-0.510
- APOPTOSIS-0.500
- INTERFERON_ALPHA_RESPONSE-0.500
- MYC_TARGETS_V1-0.500
- MTORC1_SIGNALING-0.490
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.490
- MYC_TARGETS_V2-0.460
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-E7-A7PW-01A-11R-A352-07 | — | — | 0.967 |
| 2 | SRR26320083 | — | — | 0.963 |
| 3 | aMVAC.P_005_TURBT_S223 | — | — | 0.952 |
| 4 | ERR4976608 | — | D | 0.950 |
| 5 | SRR13311179 | — | — | 0.944 |
| 6 | 8ad884fa-e426-4bc0-960d-08db42d341da | — | — | 0.940 |
| 7 | SRR26320081 | — | — | 0.936 |
| 8 | SRR934779 | — | — | 0.936 |
| 9 | MNG599 | — | — | 0.935 |
| 10 | SRR12202440 | — | — | 0.934 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.420 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.330 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.240 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.170 | Inavolisib | — uncovered |