Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · breast-umap@18

SRR8518397

— · E

3eb1f0ed-bad4-54cc-bed8-abfdcbd0ec7b

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
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cancer_type_detailed
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subtype
E
subtype
E

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1e5361f4b-702f-4404-aa03-1cb37ea109b1
melanoma-umap@29
——0.868
2BSR_12_0070_A1_S79
breast-umap@18
—C0.865
3fddf611e-f586-49e1-9ee8-8ac853accb9e
colon-landscapes@1
——0.853
4SRR1516095
bladder-landscape@3
——0.848
5TCGA-E9-A1RB-01A-11R-A157-07
breast-umap@18
—C0.836
6f20785b9-991d-4b87-8ba7-ca32373f1996
melanoma-umap@29
——0.832
73fca0833-b19b-47af-b75e-c9c45a99373b
colon-landscapes@1
——0.830
8TCGA-EW-A1OY-01A-11R-A144-07
breast-umap@18
—B0.828
9TCGA-18-3412-01A-01R-0980-07
lung-landscapes@6
—cohortSQ20.826
10C3N-03204
lung-landscapes@6
—cohortSQ20.825

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 29 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.530Inavolisib— uncovered
MYC_TARGETS_V10.430Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.400Remibrutinib— uncovered
MYC_TARGETS_V20.390Idelalisib— uncovered
G2M_CHECKPOINT0.380Inavolisib— uncovered
MTORC1_SIGNALING0.370Inavolisib— uncovered
UV_RESPONSE_UP0.300Idelalisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.290Remibrutinib— uncovered
GLYCOLYSIS0.290Inavolisib— uncovered
SPERMATOGENESIS0.290Inavolisib— uncovered
DNA_REPAIR0.230Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.220Idelalisib— uncovered
APICAL_JUNCTION0.210Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.210Idelalisib— uncovered
PEROXISOME0.200Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.200Inavolisib— uncovered
PANCREAS_BETA_CELLS0.170Cobimetinib— uncovered
ADIPOGENESIS0.150Inavolisib— uncovered
BILE_ACID_METABOLISM0.150Inavolisib— uncovered
FATTY_ACID_METABOLISM0.130Inavolisib— uncovered