Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · bladder-landscape@3

SRR1516095

—

54eb37f6-0471-51fb-8a84-7b3c6f559157

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
—
subtype
—

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V1+0.590
  • OXIDATIVE_PHOSPHORYLATION+0.590
  • E2F_TARGETS+0.540
  • MTORC1_SIGNALING+0.450
  • PROTEIN_SECRETION+0.440
  • FATTY_ACID_METABOLISM+0.400
  • G2M_CHECKPOINT+0.400
  • CHOLESTEROL_HOMEOSTASIS+0.390
  • UNFOLDED_PROTEIN_RESPONSE+0.390
  • DNA_REPAIR+0.370

Top 10 suppressed

  • HEDGEHOG_SIGNALING-0.500
  • WNT_BETA_CATENIN_SIGNALING-0.450
  • IL6_JAK_STAT3_SIGNALING-0.340
  • TNFA_SIGNALING_VIA_NFKB-0.320
  • ALLOGRAFT_REJECTION-0.310
  • UV_RESPONSE_DN-0.280
  • INFLAMMATORY_RESPONSE-0.260
  • KRAS_SIGNALING_UP-0.260
  • IL2_STAT5_SIGNALING-0.210
  • NOTCH_SIGNALING-0.210

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
13fca0833-b19b-47af-b75e-c9c45a99373b
colon-landscapes@1
——0.920
2TCGA-34-5240-01A-01R-1443-07
lung-landscapes@6
—cohortSQ20.883
3dfb9c45f-cb52-4e36-b663-1a9e8c7c0b47
colon-landscapes@1
——0.871
4518420d3-dfdf-4163-99a4-2b8d7a04056c
colon-landscapes@1
——0.852
5TCGA-AO-A0JD-01A-11R-A056-07
breast-umap@18
—C0.851
6SRR8518248
breast-umap@18
—E0.850
7SRR8518397
breast-umap@18
—E0.848
8feccc57b-a987-4dd7-babf-1a8982bd64cc
colon-landscapes@1
——0.842
9BSR_12_0070_A1_S79
breast-umap@18
—C0.841
1079a36f11-38bb-42ed-a95a-ae2a9eea0f6a
colon-landscapes@1
——0.839

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V10.590Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.590Remibrutinib— uncovered
E2F_TARGETS0.540Inavolisib— uncovered
MTORC1_SIGNALING0.450Inavolisib— uncovered
PROTEIN_SECRETION0.440Remibrutinib— uncovered
FATTY_ACID_METABOLISM0.400Inavolisib— uncovered
G2M_CHECKPOINT0.400Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.390Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.390Idelalisib— uncovered
DNA_REPAIR0.370Idelalisib— uncovered
ADIPOGENESIS0.360Inavolisib— uncovered
MYC_TARGETS_V20.360Idelalisib— uncovered
PEROXISOME0.340Idelalisib— uncovered
ANDROGEN_RESPONSE0.320Inavolisib— uncovered
PANCREAS_BETA_CELLS0.310Cobimetinib— uncovered
XENOBIOTIC_METABOLISM0.270Inavolisib— uncovered
GLYCOLYSIS0.260Inavolisib— uncovered
SPERMATOGENESIS0.200Inavolisib— uncovered
UV_RESPONSE_UP0.200Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.170Inavolisib— uncovered