MBCProject_0814_T1_RNA
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.190
- WNT_BETA_CATENIN_SIGNALING+0.120
- HEDGEHOG_SIGNALING+0.060
- NOTCH_SIGNALING+0.000
- PANCREAS_BETA_CELLS-0.010
- KRAS_SIGNALING_DN-0.040
- BILE_ACID_METABOLISM-0.050
- DNA_REPAIR-0.060
- APICAL_SURFACE-0.080
- ESTROGEN_RESPONSE_EARLY-0.080
Top 10 suppressed
- E2F_TARGETS-0.590
- INTERFERON_ALPHA_RESPONSE-0.580
- G2M_CHECKPOINT-0.520
- MTORC1_SIGNALING-0.490
- INTERFERON_GAMMA_RESPONSE-0.480
- MYC_TARGETS_V1-0.480
- PROTEIN_SECRETION-0.410
- MYC_TARGETS_V2-0.400
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.390
- MITOTIC_SPINDLE-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1313097 | — | A | 0.903 |
| 2 | TCGA-63-A5MV-01A-21R-A26W-07 | — | cohortSQ1 | 0.902 |
| 3 | TCGA-CU-A3YL-01A-11R-A22U-07 | — | — | 0.887 |
| 4 | TCGA-E7-A3Y1-01A-11R-A22U-07 | — | — | 0.880 |
| 5 | AUR-AFUN-TTP1-A-1-0-R-A741-41 | — | D | 0.878 |
| 6 | ERR4976607 | — | B | 0.877 |
| 7 | SRR1516050 | — | — | 0.875 |
| 8 | SRR1335254 | GTEX | — | 0.874 |
| 9 | d2995480-5ae0-42e1-9a21-25e1435201ee | — | — | 0.874 |
| 10 | TCGA-W8-A86G-01A-21R-A36F-07 | — | A | 0.871 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 3 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.190 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.120 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.060 | Inavolisib | — uncovered |