AUR-AFUN-TTP1-A-1-0-R-A741-41
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- UV_RESPONSE_DN+0.280
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.180
- ESTROGEN_RESPONSE_EARLY+0.060
- ANGIOGENESIS-0.010
- HEDGEHOG_SIGNALING-0.010
- NOTCH_SIGNALING-0.020
- PANCREAS_BETA_CELLS-0.040
- HEME_METABOLISM-0.060
- KRAS_SIGNALING_UP-0.070
- APICAL_JUNCTION-0.080
Top 10 suppressed
- MYC_TARGETS_V1-0.590
- MYC_TARGETS_V2-0.590
- OXIDATIVE_PHOSPHORYLATION-0.560
- INTERFERON_ALPHA_RESPONSE-0.510
- E2F_TARGETS-0.500
- MTORC1_SIGNALING-0.500
- CHOLESTEROL_HOMEOSTASIS-0.470
- UNFOLDED_PROTEIN_RESPONSE-0.450
- INTERFERON_GAMMA_RESPONSE-0.440
- ADIPOGENESIS-0.420
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-A7-A13G-01B-04R-A22O-07 | — | D | 0.927 |
| 2 | 4f0b1ac0-c503-4852-9a44-cb4231f4b17b | — | — | 0.910 |
| 3 | AUR-AFKB-TTP1-A-10-0-R-A741-41 | — | D | 0.906 |
| 4 | TCGA-A7-A0DB-01C-02R-A277-07 | — | D | 0.893 |
| 5 | TCGA-A7-A26E-01B-06R-A277-07 | — | D | 0.889 |
| 6 | TCGA-CN-4737-01A-01R-1436-07 | — | — | 0.886 |
| 7 | fe036511-fe82-467c-9c6e-59bfb8b0a329 | — | — | 0.885 |
| 8 | MNG532 | — | — | 0.881 |
| 9 | TCGA-A7-A0DC-01B-04R-A22O-07 | — | D | 0.878 |
| 10 | MBCProject_0814_T1_RNA | — | A | 0.878 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 3 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| UV_RESPONSE_DN | 0.280 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.180 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.060 | Inavolisib | — uncovered |