Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · medullo-epn-umap@date-based

ERR2598079

fetal · fetal

41b5e579-1fd6-5b81-bb03-cc2b69b8b920

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
fetal
cancer_type_detailed
—
subtype
fetal
cancer_type
fetal
subtype
fetal
sex
fetal
race
fetal
fetal_age_hindbrain
11
umap1_2d
-3.629080947
umap2_2d
3.793539217
umap1_3d
-1.744471832
umap2_3d
2.378692823
umap3_3d
-1.212129799
dataset
fetal

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • HEDGEHOG_SIGNALING+0.480
  • PROTEIN_SECRETION+0.360
  • UV_RESPONSE_DN+0.340
  • TGF_BETA_SIGNALING+0.330
  • PANCREAS_BETA_CELLS+0.290
  • ANDROGEN_RESPONSE+0.270
  • ESTROGEN_RESPONSE_EARLY+0.240
  • NOTCH_SIGNALING+0.230
  • SPERMATOGENESIS+0.210
  • APICAL_JUNCTION+0.160

Top 10 suppressed

  • MYC_TARGETS_V2-0.430
  • DNA_REPAIR-0.370
  • E2F_TARGETS-0.370
  • MYC_TARGETS_V1-0.360
  • INTERFERON_ALPHA_RESPONSE-0.330
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.260
  • G2M_CHECKPOINT-0.250
  • INTERFERON_GAMMA_RESPONSE-0.200
  • OXIDATIVE_PHOSPHORYLATION-0.200
  • ALLOGRAFT_REJECTION-0.160

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ERR2598057
medullo-epn-umap@date-based
fetalfetal0.859
2MDT-AP-0103
medullo-epn-umap@date-based
MedMedulloblastoma0.796
3TCGA-AR-A24W-01A-11R-A169-07
breast-umap@18
—A0.789
4TCGA-A1-A0SH-01A-11R-A084-07
breast-umap@18
—A0.789
5MNG435
mng-umap@100
——0.768
6TCGA-CR-7397-01A-11R-2016-07
head-neck@1
——0.764
7BS_GV3NZ9QD
medullo-epn-umap@date-based
EPNEPN Tumor0.756
8fb5d10ba-36f3-4236-b8fd-7c057db51039
colon-landscapes@1
——0.754
9MNG121
mng-umap@100
——0.751
10TCGA-A1-A0SM-01A-11R-A084-07
breast-umap@18
—C0.751

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 29 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
HEDGEHOG_SIGNALING0.480Inavolisib— uncovered
PROTEIN_SECRETION0.360Remibrutinib— uncovered
UV_RESPONSE_DN0.340Inavolisib— uncovered
TGF_BETA_SIGNALING0.330Inavolisib— uncovered
PANCREAS_BETA_CELLS0.290Cobimetinib— uncovered
ANDROGEN_RESPONSE0.270Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.240Inavolisib— uncovered
NOTCH_SIGNALING0.230Inavolisib— uncovered
SPERMATOGENESIS0.210Inavolisib— uncovered
APICAL_JUNCTION0.160Inavolisib— uncovered
HYPOXIA0.160Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.160Inavolisib— uncovered
KRAS_SIGNALING_UP0.140Inavolisib— uncovered
MITOTIC_SPINDLE0.140Inavolisib— uncovered
GLYCOLYSIS0.130Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.130Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.110Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.100Inavolisib— uncovered
ANGIOGENESIS0.080Remibrutinib— uncovered
ESTROGEN_RESPONSE_LATE0.080Idelalisib— uncovered