Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · medullo-epn-umap@date-based

ERR2598057

fetal · fetal

8e608a3b-6f4c-5072-bd6a-582a545b8211

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
fetal
cancer_type_detailed
—
subtype
fetal
cancer_type
fetal
subtype
fetal
sex
fetal
race
fetal
fetal_age_hindbrain
10
umap1_2d
-3.673982687
umap2_2d
3.926929156
umap1_3d
-1.650918363
umap2_3d
2.206348846
umap3_3d
-1.062003589
dataset
fetal

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • HEDGEHOG_SIGNALING+0.490
  • UV_RESPONSE_DN+0.410
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.400
  • TGF_BETA_SIGNALING+0.340
  • ESTROGEN_RESPONSE_EARLY+0.320
  • COAGULATION+0.310
  • HYPOXIA+0.310
  • ANDROGEN_RESPONSE+0.290
  • PROTEIN_SECRETION+0.290
  • KRAS_SIGNALING_UP+0.260

Top 10 suppressed

  • MYC_TARGETS_V2-0.440
  • DNA_REPAIR-0.370
  • MYC_TARGETS_V1-0.280
  • E2F_TARGETS-0.250
  • OXIDATIVE_PHOSPHORYLATION-0.190
  • ALLOGRAFT_REJECTION-0.130
  • G2M_CHECKPOINT-0.120
  • INTERFERON_ALPHA_RESPONSE-0.120
  • UNFOLDED_PROTEIN_RESPONSE-0.100
  • UV_RESPONSE_UP-0.090

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ERR2598110
medullo-epn-umap@date-based
fetalfetal0.893
2TCGA-AC-A23E-01A-11R-A157-07
breast-umap@18
—A0.865
3ERR2598079
medullo-epn-umap@date-based
fetalfetal0.859
420030015.LumB
breast-umap@18
—A0.857
5MNG119
mng-umap@100
——0.844
64c7083b3-eccc-4d80-a31d-6fd3cd0222b4
colon-landscapes@1
——0.829
7MNG115
mng-umap@100
——0.826
8SRR15069612
head-neck@1
——0.824
9TCGA-CV-7236-01A-11R-2016-07
head-neck@1
——0.823
10TCGA-64-1679-01A-21R-2066-07
lung-landscapes@6
—cohortA10.822

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
HEDGEHOG_SIGNALING0.490Inavolisib— uncovered
UV_RESPONSE_DN0.410Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.400Inavolisib— uncovered
TGF_BETA_SIGNALING0.340Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.320Inavolisib— uncovered
COAGULATION0.310Binimetinib— uncovered
HYPOXIA0.310Idelalisib— uncovered
ANDROGEN_RESPONSE0.290Inavolisib— uncovered
PROTEIN_SECRETION0.290Remibrutinib— uncovered
KRAS_SIGNALING_UP0.260Inavolisib— uncovered
PANCREAS_BETA_CELLS0.250Cobimetinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.250Inavolisib— uncovered
APICAL_JUNCTION0.240Inavolisib— uncovered
SPERMATOGENESIS0.240Inavolisib— uncovered
ANGIOGENESIS0.220Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.170Idelalisib— uncovered
BILE_ACID_METABOLISM0.160Inavolisib— uncovered
MITOTIC_SPINDLE0.160Inavolisib— uncovered
HEME_METABOLISM0.150Temsirolimus— uncovered
ESTROGEN_RESPONSE_LATE0.140Idelalisib— uncovered