MNG1220
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.356
- PROTEIN_SECRETION+0.343
- MITOTIC_SPINDLE+0.307
- G2M_CHECKPOINT+0.299
- PI3K_AKT_MTOR_SIGNALING+0.235
- DNA_REPAIR+0.209
- UV_RESPONSE_DN+0.196
- MYC_TARGETS_V1+0.189
- PEROXISOME+0.166
- UNFOLDED_PROTEIN_RESPONSE+0.129
Top 10 suppressed
- ANGIOGENESIS-0.514
- TNFA_SIGNALING_VIA_NFKB-0.409
- PANCREAS_BETA_CELLS-0.386
- HEDGEHOG_SIGNALING-0.375
- P53_PATHWAY-0.326
- HYPOXIA-0.318
- KRAS_SIGNALING_DN-0.255
- OXIDATIVE_PHOSPHORYLATION-0.255
- ESTROGEN_RESPONSE_LATE-0.249
- APOPTOSIS-0.227
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-2641 | Med | Medulloblastoma | 0.825 |
| 2 | MDT-AP-3288 | Med | Medulloblastoma | 0.818 |
| 3 | MNG388 | — | — | 0.805 |
| 4 | MNG1027 | — | — | 0.801 |
| 5 | MNG274 | — | — | 0.787 |
| 6 | MNG504 | — | — | 0.785 |
| 7 | MNG909 | — | — | 0.778 |
| 8 | MNG724 | — | — | 0.774 |
| 9 | R181 | — | — | 0.774 |
| 10 | MNG642 | — | — | 0.773 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 17 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.356 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.343 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.307 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.299 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.235 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.209 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.196 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.189 | Inavolisib | — uncovered |
| PEROXISOME | 0.166 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.129 | Idelalisib | — uncovered |
| HEME_METABOLISM | 0.128 | Temsirolimus | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.096 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.094 | Idelalisib | — uncovered |
| TGF_BETA_SIGNALING | 0.069 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.064 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.035 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.017 | Inavolisib | — uncovered |