TCGA-A8-A09V-01A-11R-A034-07
— · B
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- B
- subtype
- B
- overall_survival_months
- 15
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MITOTIC_SPINDLE+0.360
- UV_RESPONSE_DN+0.280
- NOTCH_SIGNALING+0.180
- ESTROGEN_RESPONSE_EARLY+0.110
- TGF_BETA_SIGNALING+0.070
- HEDGEHOG_SIGNALING+0.030
- G2M_CHECKPOINT-0.010
- HEME_METABOLISM-0.010
- PROTEIN_SECRETION-0.010
- WNT_BETA_CATENIN_SIGNALING-0.010
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.550
- INTERFERON_GAMMA_RESPONSE-0.510
- INTERFERON_ALPHA_RESPONSE-0.490
- INFLAMMATORY_RESPONSE-0.470
- OXIDATIVE_PHOSPHORYLATION-0.470
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.470
- MYC_TARGETS_V2-0.460
- TNFA_SIGNALING_VIA_NFKB-0.460
- CHOLESTEROL_HOMEOSTASIS-0.450
- MTORC1_SIGNALING-0.440
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-A7-A0DC-01B-04R-A22O-07 | — | D | 0.910 |
| 2 | MBCProject_0226_T1_RNA | — | A | 0.894 |
| 3 | TCGA-A7-A13G-01B-04R-A22O-07 | — | D | 0.880 |
| 4 | TCGA-A7-A0DB-01C-02R-A277-07 | — | D | 0.876 |
| 5 | TCGA-BL-A0C8-01B-04R-A277-07 | — | — | 0.875 |
| 6 | ERR2598056 | fetal | fetal | 0.873 |
| 7 | 302722c6-102e-4b1b-845e-78920380e337 | — | — | 0.871 |
| 8 | TCGA-GU-A42R-01A-11R-A23N-07 | — | — | 0.868 |
| 9 | s0102877 | — | — | 0.865 |
| 10 | 69550f7f-5251-4657-863b-bd35d69c82c4 | — | — | 0.864 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MITOTIC_SPINDLE | 0.360 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.280 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.180 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.110 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.070 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.030 | Inavolisib | — uncovered |