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TCGA-A7-A13G-01B-04R-A22O-07

· D

8c3501cc-2df4-5534-8089-595b3e100937

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
D
subtype
D
overall_survival_months
24

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • UV_RESPONSE_DN+0.250
  • MITOTIC_SPINDLE+0.130
  • HEDGEHOG_SIGNALING+0.090
  • TGF_BETA_SIGNALING+0.060
  • SPERMATOGENESIS-0.040
  • HEME_METABOLISM-0.060
  • KRAS_SIGNALING_DN-0.070
  • NOTCH_SIGNALING-0.080
  • BILE_ACID_METABOLISM-0.100
  • APICAL_SURFACE-0.150

Top 10 suppressed

  • MYC_TARGETS_V2-0.640
  • MYC_TARGETS_V1-0.630
  • E2F_TARGETS-0.550
  • OXIDATIVE_PHOSPHORYLATION-0.540
  • MTORC1_SIGNALING-0.520
  • REACTIVE_OXYGEN_SPECIES_PATHWAY-0.490
  • UV_RESPONSE_UP-0.480
  • CHOLESTEROL_HOMEOSTASIS-0.460
  • DNA_REPAIR-0.460
  • UNFOLDED_PROTEIN_RESPONSE-0.450

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-A7-A0DC-01B-04R-A22O-07
breast-umap@18
D0.938
2MDT-AP-3267
medullo-epn-umap@date-based
MedMedulloblastoma0.932
3ed8896f8-24ef-43a4-ace6-ed9353bd11c2
colon-landscapes@1
0.930
4TCGA-A7-A0DB-01C-02R-A277-07
breast-umap@18
D0.928
5TCGA-A7-A26E-01B-06R-A277-07
breast-umap@18
D0.928
6AUR-AFUN-TTP1-A-1-0-R-A741-41
breast-umap@18
D0.927
762454053-936d-4f19-8522-6219c47bdd1c
colon-landscapes@1
0.926
8ERR2598056
medullo-epn-umap@date-based
fetalfetal0.925
9b8135e73-31c3-49af-b4da-a7ed5f28d68a
colon-landscapes@1
0.917
1069550f7f-5251-4657-863b-bd35d69c82c4
colon-landscapes@1
0.903

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
UV_RESPONSE_DN0.250Inavolisib— uncovered
MITOTIC_SPINDLE0.130Inavolisib— uncovered
HEDGEHOG_SIGNALING0.090Inavolisib— uncovered
TGF_BETA_SIGNALING0.060Inavolisib— uncovered