Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-A7-A0CJ-01A-21R-A00Z-07

· B

47a5156e-1455-5368-af37-4b53c660e0ba

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
31

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR15030853
colon-landscapes@1
0.897
2TCGA-A2-A0CW-01A-21R-A115-07
breast-umap@18
B0.874
3SRR8613729
breast-umap@18
E0.871
4TCGA-EW-A1OY-01A-11R-A144-07
breast-umap@18
B0.853
5SRR8518179
breast-umap@18
E0.852
6TCGA-CV-6003-01A-11R-1686-07
head-neck@1
0.851
7TCGA-XF-A9T6-01A-11R-A42T-07
bladder-landscape@3
0.849
8SRR8518230
breast-umap@18
E0.848
9SRR25617854
breast-umap@18
C0.846
10TCGA-A8-A092-01A-11R-A00Z-07
breast-umap@18
B0.845

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.590Idelalisib— uncovered
E2F_TARGETS0.530Inavolisib— uncovered
MYC_TARGETS_V10.510Inavolisib— uncovered
G2M_CHECKPOINT0.450Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.440Inavolisib— uncovered
DNA_REPAIR0.410Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.390Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.350Remibrutinib— uncovered
MTORC1_SIGNALING0.340Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.270Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.220Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.160Idelalisib— uncovered
FATTY_ACID_METABOLISM0.140Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.140Inavolisib— uncovered
SPERMATOGENESIS0.140Inavolisib— uncovered
UV_RESPONSE_UP0.140Idelalisib— uncovered
ADIPOGENESIS0.120Inavolisib— uncovered
GLYCOLYSIS0.120Inavolisib— uncovered
MITOTIC_SPINDLE0.120Inavolisib— uncovered
HYPOXIA0.070Idelalisib— uncovered