Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-XF-A9T6-01A-11R-A42T-07

0d36a46c-09bd-5529-bab8-caeb1e356d2c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
2.102496715
os_event
false
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR2016960
head-neck@1
0.864
2TCGA-T3-A92N-01A-11R-A39I-07
head-neck@1
0.863
3SRR8518360
breast-umap@18
E0.851
478699d1d-aa39-473a-b3ea-24164d3a443c
colon-landscapes@1
0.851
5SRR8518323
breast-umap@18
E0.850
6TCGA-HD-7832-01A-11R-2132-07
head-neck@1
0.850
7TCGA-A7-A0CJ-01A-21R-A00Z-07
breast-umap@18
B0.849
8SRR11296765
colon-landscapes@1
0.849
9TCGA-PQ-A6FI-01A-11R-A31N-07
bladder-landscape@3
0.843
10TCGA-CV-6003-01A-11R-1686-07
head-neck@1
0.843

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 28 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.650Idelalisib— uncovered
MYC_TARGETS_V10.570Inavolisib— uncovered
E2F_TARGETS0.560Inavolisib— uncovered
DNA_REPAIR0.490Idelalisib— uncovered
G2M_CHECKPOINT0.400Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.380Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.310Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.300Inavolisib— uncovered
MTORC1_SIGNALING0.280Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.270Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.230Idelalisib— uncovered
GLYCOLYSIS0.210Inavolisib— uncovered
MITOTIC_SPINDLE0.160Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.150Idelalisib— uncovered
UV_RESPONSE_UP0.140Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.110Inavolisib— uncovered
FATTY_ACID_METABOLISM0.090Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.090Idelalisib— uncovered
APOPTOSIS0.080Idelalisib— uncovered
NOTCH_SIGNALING0.080Inavolisib— uncovered