a50c02ec-6ba9-4678-990d-6c74a8e9b7b5
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 53
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- BILE_ACID_METABOLISM+0.110
- KRAS_SIGNALING_DN+0.100
- WNT_BETA_CATENIN_SIGNALING+0.100
- PEROXISOME+0.070
- MYC_TARGETS_V2+0.060
- MITOTIC_SPINDLE+0.050
- SPERMATOGENESIS+0.030
- G2M_CHECKPOINT-0.060
- ESTROGEN_RESPONSE_EARLY-0.110
- HEME_METABOLISM-0.120
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.570
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.560
- INTERFERON_GAMMA_RESPONSE-0.510
- ANGIOGENESIS-0.500
- TNFA_SIGNALING_VIA_NFKB-0.500
- IL6_JAK_STAT3_SIGNALING-0.440
- INFLAMMATORY_RESPONSE-0.440
- INTERFERON_ALPHA_RESPONSE-0.430
- KRAS_SIGNALING_UP-0.420
- COMPLEMENT-0.410
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
1 twin match this tumor's tissue · 9 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1478096 | GTEX | — | 0.935 |
| 2 | SRR1456514 | GTEX | — | 0.935 |
| 3 | SRR1377984 | GTEX | — | 0.935 |
| 4 | SRR1324452 | GTEX | — | 0.934 |
| 5 | SRR607967 | GTEX | — | 0.933 |
| 6 | SRR1467255 | GTEX | — | 0.930 |
| 7 | TCGA-L9-A7SV-01A-11R-A39D-07 | — | cohortA1 | 0.930 |
| 8 | SRR1322291 | GTEX | — | 0.929 |
| 9 | SRR1398992 | GTEX | — | 0.929 |
| 10 | SRR1341605 | GTEX | — | 0.926 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| BILE_ACID_METABOLISM | 0.110 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.100 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.100 | Inavolisib | — uncovered |
| PEROXISOME | 0.070 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.060 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.050 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.030 | Inavolisib | — uncovered |