TCGA-L9-A7SV-01A-11R-A39D-07
— · cohortA1
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA1
- subtype
- cohortA1
- age_years
- 69
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.140
- KRAS_SIGNALING_DN+0.080
- BILE_ACID_METABOLISM+0.070
- MITOTIC_SPINDLE+0.020
- MYC_TARGETS_V2-0.010
- NOTCH_SIGNALING-0.020
- PEROXISOME-0.090
- E2F_TARGETS-0.110
- MYOGENESIS-0.110
- HEME_METABOLISM-0.120
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.540
- ANGIOGENESIS-0.510
- INTERFERON_GAMMA_RESPONSE-0.470
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.470
- ALLOGRAFT_REJECTION-0.460
- INTERFERON_ALPHA_RESPONSE-0.460
- APICAL_SURFACE-0.440
- COMPLEMENT-0.440
- TGF_BETA_SIGNALING-0.440
- INFLAMMATORY_RESPONSE-0.430
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-FJ-A3ZF-01A-11R-A23N-07 | — | — | 0.943 |
| 2 | SRR650166 | — | — | 0.937 |
| 3 | SRR1456514 | GTEX | — | 0.936 |
| 4 | SRR1377984 | GTEX | — | 0.935 |
| 5 | SRR607967 | GTEX | — | 0.934 |
| 6 | SRR1474754 | GTEX | — | 0.930 |
| 7 | a50c02ec-6ba9-4678-990d-6c74a8e9b7b5 | — | — | 0.930 |
| 8 | SRR1459033 | GTEX | — | 0.929 |
| 9 | SRR1341605 | GTEX | — | 0.925 |
| 10 | SRR1478096 | GTEX | — | 0.924 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.140 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.080 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.070 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.020 | Inavolisib | — uncovered |