Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · medullo-epn-umap@date-based

MDT-AP-2658

Med · Medulloblastoma

49d7a4a4-b5e3-531a-ae1a-50ff985ac031

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Med
cancer_type_detailed
—
subtype
Medulloblastoma
cancer_type
Med
subtype
Medulloblastoma
os_event
false
age_years
16
sex
M
new_clusters
C4
umap1_2d
3.373546306
umap2_2d
4.303902209
umap1_3d
0.734622459
umap2_3d
-0.560903671
umap3_3d
-2.30058841
dataset
Med-Taylor

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ALLOGRAFT_REJECTION+0.550
  • INFLAMMATORY_RESPONSE+0.470
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.430
  • KRAS_SIGNALING_UP+0.430
  • COMPLEMENT+0.420
  • TNFA_SIGNALING_VIA_NFKB+0.410
  • ANGIOGENESIS+0.400
  • INTERFERON_GAMMA_RESPONSE+0.380
  • IL6_JAK_STAT3_SIGNALING+0.350
  • COAGULATION+0.340

Top 10 suppressed

  • MYC_TARGETS_V2-0.390
  • WNT_BETA_CATENIN_SIGNALING-0.300
  • MITOTIC_SPINDLE-0.270
  • UNFOLDED_PROTEIN_RESPONSE-0.260
  • DNA_REPAIR-0.230
  • OXIDATIVE_PHOSPHORYLATION-0.220
  • E2F_TARGETS-0.210
  • FATTY_ACID_METABOLISM-0.160
  • G2M_CHECKPOINT-0.140
  • MYC_TARGETS_V1-0.130

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-22-4596-01A-01R-1201-07
lung-landscapes@6
—cohortA10.911
2MDT-AP-2869
medullo-epn-umap@date-based
MedMedulloblastoma0.908
3MDT-AP-2936
medullo-epn-umap@date-based
MedMedulloblastoma0.904
4TCGA-44-7672-01A-11R-2066-07
lung-landscapes@6
—cohortA10.902
5sclc0617_S65.txt
lung-landscapes@6
—cohortMD20.901
6MDT-AP-2638
medullo-epn-umap@date-based
MedMedulloblastoma0.899
7MDT-AP-2743
medullo-epn-umap@date-based
MedMedulloblastoma0.898
8BS_3H71BH6Q
brain-umap@2
Ganglioglioma—0.897
9MDT-AP-3331
medullo-epn-umap@date-based
MedMedulloblastoma0.896
10MDT-AP-0484
medullo-epn-umap@date-based
MedMedulloblastoma0.896

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 31 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.550Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.470Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.430Inavolisib— uncovered
KRAS_SIGNALING_UP0.430Inavolisib— uncovered
COMPLEMENT0.420Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.410Inavolisib— uncovered
ANGIOGENESIS0.400Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.380Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.350Inavolisib— uncovered
COAGULATION0.340Binimetinib— uncovered
IL2_STAT5_SIGNALING0.330Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.260Inavolisib— uncovered
HYPOXIA0.230Idelalisib— uncovered
APICAL_SURFACE0.220Temsirolimus— uncovered
PANCREAS_BETA_CELLS0.220Cobimetinib— uncovered
APOPTOSIS0.210Idelalisib— uncovered
TGF_BETA_SIGNALING0.200Inavolisib— uncovered
HEDGEHOG_SIGNALING0.190Inavolisib— uncovered
MYOGENESIS0.190Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.190Inavolisib— uncovered