Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

MDT-AP-2869

Med · Medulloblastoma

df34f1bb-da94-5dfb-984c-339eb04f6712

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Med
cancer_type_detailed
subtype
Medulloblastoma
cancer_type
Med
subtype
Medulloblastoma
overall_survival_months
18.96
os_event
false
age_years
11
sex
M
new_clusters
C4
umap1_2d
3.951752678
umap2_2d
4.380811247
umap1_3d
1.075749385
umap2_3d
-1.040993731
umap3_3d
-2.6466399
dataset
Med-Taylor

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_1RXZ3BP7
brain-umap@2
low-grade glioma0.950
2BS_YY5B2XDD
brain-umap@2
pilocytic astrocytoma0.947
3MDT-AP-2936
medullo-epn-umap@date-based
MedMedulloblastoma0.943
4BS_W97QQYKQ
brain-umap@2
Ganglioglioma0.938
5MDT-AP-3331
medullo-epn-umap@date-based
MedMedulloblastoma0.935
6s0122206
melanoma-umap@29
0.934
7MDT-AP-3277
medullo-epn-umap@date-based
MedMedulloblastoma0.933
8TCGA-77-8131-01A-11R-2247-07
lung-landscapes@6
cohortSQ10.932
9MDT-AP-0363
medullo-epn-umap@date-based
MedMedulloblastoma0.932
10BS_S9929Z8B
brain-umap@2
Ganglioglioma0.932

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 35 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.590Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.580Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.570Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.560Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.560Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.550Inavolisib— uncovered
KRAS_SIGNALING_UP0.520Inavolisib— uncovered
ANGIOGENESIS0.500Remibrutinib— uncovered
COMPLEMENT0.470Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.460Inavolisib— uncovered
IL2_STAT5_SIGNALING0.430Idelalisib— uncovered
COAGULATION0.380Binimetinib— uncovered
APOPTOSIS0.370Idelalisib— uncovered
APICAL_SURFACE0.310Temsirolimus— uncovered
ESTROGEN_RESPONSE_LATE0.290Idelalisib— uncovered
TGF_BETA_SIGNALING0.290Inavolisib— uncovered
APICAL_JUNCTION0.260Inavolisib— uncovered
HEDGEHOG_SIGNALING0.250Inavolisib— uncovered
MYOGENESIS0.240Inavolisib— uncovered
P53_PATHWAY0.240Idelalisib— uncovered