GSM6454742
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.310
- WNT_BETA_CATENIN_SIGNALING+0.280
- P53_PATHWAY+0.200
- HEDGEHOG_SIGNALING+0.170
- MYOGENESIS+0.170
- ALLOGRAFT_REJECTION+0.150
- APICAL_JUNCTION+0.110
- APICAL_SURFACE+0.100
- IL6_JAK_STAT3_SIGNALING+0.090
- TGF_BETA_SIGNALING+0.070
Top 10 suppressed
- PROTEIN_SECRETION-0.590
- MYC_TARGETS_V1-0.490
- OXIDATIVE_PHOSPHORYLATION-0.410
- MTORC1_SIGNALING-0.390
- ANDROGEN_RESPONSE-0.370
- E2F_TARGETS-0.350
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.350
- UNFOLDED_PROTEIN_RESPONSE-0.350
- ADIPOGENESIS-0.340
- ANGIOGENESIS-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12696780 | — | — | 0.857 |
| 2 | MNG1087 | — | — | 0.855 |
| 3 | R186 | — | — | 0.852 |
| 4 | 9176b038-65e3-469d-a867-d99bc732e45d | — | — | 0.846 |
| 5 | MNG1258 | — | — | 0.840 |
| 6 | d406bb03-1a9a-4aa3-a1a8-4de5478b4701 | — | — | 0.836 |
| 7 | SRR4195667 | — | — | 0.831 |
| 8 | SRR8942953 | — | — | 0.827 |
| 9 | MBCProject_0003_T2_RNA | — | A | 0.817 |
| 10 | R96 | — | — | 0.816 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.310 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.280 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.200 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.170 | Inavolisib | — uncovered |
| MYOGENESIS | 0.170 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.150 | Idelalisib | — uncovered |
| APICAL_JUNCTION | 0.110 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.100 | Temsirolimus | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.090 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.070 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.010 | Inavolisib | — uncovered |