SRR35579798
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.550
- INTERFERON_GAMMA_RESPONSE+0.490
- E2F_TARGETS+0.440
- IL6_JAK_STAT3_SIGNALING+0.430
- ALLOGRAFT_REJECTION+0.410
- G2M_CHECKPOINT+0.400
- INFLAMMATORY_RESPONSE+0.350
- MITOTIC_SPINDLE+0.300
- COMPLEMENT+0.260
- MYC_TARGETS_V2+0.260
Top 10 suppressed
- ESTROGEN_RESPONSE_EARLY-0.470
- ANGIOGENESIS-0.440
- ESTROGEN_RESPONSE_LATE-0.390
- MYOGENESIS-0.350
- ANDROGEN_RESPONSE-0.320
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.320
- OXIDATIVE_PHOSPHORYLATION-0.320
- CHOLESTEROL_HOMEOSTASIS-0.310
- APICAL_SURFACE-0.300
- TGF_BETA_SIGNALING-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-B6-A0RT-01A-21R-A084-07 | — | D | 0.869 |
| 2 | SRR8613746 | — | D | 0.840 |
| 3 | SRR8613734 | — | D | 0.840 |
| 4 | MBCproject_0095_T3_RNA | — | E | 0.829 |
| 5 | MBCProject_5971_T1_RNA | — | D | 0.829 |
| 6 | TCGA-AR-A1AW-01A-21R-A12P-07 | — | D | 0.818 |
| 7 | SRR1313128 | — | D | 0.815 |
| 8 | SRR8942983 | — | — | 0.811 |
| 9 | TCGA-GM-A2DH-01A-11R-A180-07 | — | C | 0.810 |
| 10 | AUR-AF95-TTP1-A-1-0-R-A741-41 | — | D | 0.805 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 19 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.550 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.490 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.440 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.430 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.410 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.400 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.350 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.300 | Inavolisib | — uncovered |
| COMPLEMENT | 0.260 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.260 | Idelalisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.190 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.130 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.080 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.070 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.060 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.050 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.050 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.020 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.010 | Inavolisib | — uncovered |