SRR5088900
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.300
- MYOGENESIS+0.300
- PANCREAS_BETA_CELLS+0.300
- COAGULATION+0.200
- ESTROGEN_RESPONSE_EARLY+0.200
- APICAL_JUNCTION+0.100
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.100
- ESTROGEN_RESPONSE_LATE+0.100
- NOTCH_SIGNALING+0.100
- P53_PATHWAY+0.100
Top 10 suppressed
- E2F_TARGETS-0.500
- IL6_JAK_STAT3_SIGNALING-0.500
- MTORC1_SIGNALING-0.500
- PROTEIN_SECRETION-0.500
- UNFOLDED_PROTEIN_RESPONSE-0.500
- ADIPOGENESIS-0.400
- ALLOGRAFT_REJECTION-0.400
- G2M_CHECKPOINT-0.400
- INTERFERON_GAMMA_RESPONSE-0.400
- MITOTIC_SPINDLE-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-W8-A86G-01A-21R-A36F-07 | — | A | 0.901 |
| 2 | TCGA-KQ-A41N-01A-11R-A33J-07 | — | — | 0.896 |
| 3 | MNG771 | — | — | 0.888 |
| 4 | TCGA-E7-A4XJ-01A-11R-A26T-07 | — | — | 0.888 |
| 5 | SRR5088871 | — | — | 0.880 |
| 6 | ERR4976607 | — | B | 0.879 |
| 7 | SRR650204 | — | — | 0.876 |
| 8 | MNG1258 | — | — | 0.876 |
| 9 | ERR4976602 | — | C | 0.876 |
| 10 | SRR1392637 | GTEX | — | 0.873 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.300 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.300 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.300 | Cobimetinib | — uncovered |
| COAGULATION | 0.200 | Binimetinib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.200 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.100 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.100 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.100 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.100 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.100 | Idelalisib | — uncovered |