SRR1392637
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.434
- HEDGEHOG_SIGNALING+0.265
- SPERMATOGENESIS+0.256
- MYOGENESIS+0.200
- ESTROGEN_RESPONSE_EARLY+0.168
- ESTROGEN_RESPONSE_LATE+0.155
- COAGULATION+0.094
- APICAL_SURFACE+0.070
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.051
- APICAL_JUNCTION+0.028
Top 10 suppressed
- MYC_TARGETS_V1-0.607
- MTORC1_SIGNALING-0.507
- UNFOLDED_PROTEIN_RESPONSE-0.493
- DNA_REPAIR-0.485
- MYC_TARGETS_V2-0.473
- E2F_TARGETS-0.450
- G2M_CHECKPOINT-0.443
- IL6_JAK_STAT3_SIGNALING-0.438
- PROTEIN_SECRETION-0.434
- ANDROGEN_RESPONSE-0.393
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1402454 | GTEX | — | 0.981 |
| 2 | SRR1457597 | GTEX | — | 0.970 |
| 3 | SRR1406561 | GTEX | — | 0.958 |
| 4 | SRR1466850 | GTEX | — | 0.957 |
| 5 | SRR1466641 | GTEX | — | 0.955 |
| 6 | SRR1336357 | GTEX | — | 0.954 |
| 7 | SRR1362417 | GTEX | — | 0.953 |
| 8 | SRR1432343 | GTEX | — | 0.948 |
| 9 | SRR1315269 | GTEX | — | 0.946 |
| 10 | BS_SM8VQFPD | DNET | — | 0.944 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.434 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.265 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.256 | Inavolisib | — uncovered |
| MYOGENESIS | 0.200 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.168 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.155 | Idelalisib | — uncovered |
| COAGULATION | 0.094 | Binimetinib | — uncovered |
| APICAL_SURFACE | 0.070 | Temsirolimus | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.051 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.028 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.025 | Inavolisib | — uncovered |