SRR9879266
— · cohortMD2
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortMD2
- subtype
- cohortMD2
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MITOTIC_SPINDLE+0.440
- ALLOGRAFT_REJECTION+0.350
- INTERFERON_GAMMA_RESPONSE+0.350
- INTERFERON_ALPHA_RESPONSE+0.340
- PROTEIN_SECRETION+0.300
- G2M_CHECKPOINT+0.260
- UV_RESPONSE_DN+0.250
- E2F_TARGETS+0.200
- FATTY_ACID_METABOLISM+0.160
- IL6_JAK_STAT3_SIGNALING+0.160
Top 10 suppressed
- ANGIOGENESIS-0.430
- TNFA_SIGNALING_VIA_NFKB-0.370
- HYPOXIA-0.350
- ESTROGEN_RESPONSE_EARLY-0.320
- P53_PATHWAY-0.320
- COAGULATION-0.300
- ESTROGEN_RESPONSE_LATE-0.300
- PANCREAS_BETA_CELLS-0.300
- WNT_BETA_CATENIN_SIGNALING-0.300
- UV_RESPONSE_UP-0.270
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 6b375859-116e-4a5e-b5b4-994a56cc9a75 | — | — | 0.859 |
| 2 | e0b0b87d-1125-4834-8133-5d719f1fd255 | — | — | 0.798 |
| 3 | MNG724 | — | — | 0.797 |
| 4 | MDT-AP-3309 | Med | Medulloblastoma | 0.797 |
| 5 | MNG833 | — | — | 0.789 |
| 6 | GSM6454730 | — | D | 0.777 |
| 7 | aMVAC.P_006_TURBT_S224 | — | — | 0.775 |
| 8 | MNG1220 | — | — | 0.772 |
| 9 | b652254e-228b-40d4-be79-536ad87dad69 | — | — | 0.768 |
| 10 | MNG1021 | — | — | 0.751 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 19 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MITOTIC_SPINDLE | 0.440 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.350 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.350 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.340 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.300 | Remibrutinib | — uncovered |
| G2M_CHECKPOINT | 0.260 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.250 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.200 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.160 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.160 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.160 | Idelalisib | — uncovered |
| COMPLEMENT | 0.090 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.070 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.050 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.050 | Temsirolimus | — uncovered |
| PEROXISOME | 0.040 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.040 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.020 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.010 | Idelalisib | — uncovered |