SRR1387072
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.200
- UNFOLDED_PROTEIN_RESPONSE+0.179
- PI3K_AKT_MTOR_SIGNALING+0.148
- OXIDATIVE_PHOSPHORYLATION+0.142
- MYC_TARGETS_V2+0.134
- DNA_REPAIR+0.123
- MYC_TARGETS_V1+0.112
- UV_RESPONSE_UP+0.075
- ANDROGEN_RESPONSE+0.036
- KRAS_SIGNALING_DN+0.024
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.577
- INTERFERON_GAMMA_RESPONSE-0.486
- INFLAMMATORY_RESPONSE-0.464
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.461
- COAGULATION-0.458
- ALLOGRAFT_REJECTION-0.417
- ANGIOGENESIS-0.402
- KRAS_SIGNALING_UP-0.401
- NOTCH_SIGNALING-0.383
- IL6_JAK_STAT3_SIGNALING-0.382
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1488751 | GTEX | — | 0.968 |
| 2 | SRR1343115 | GTEX | — | 0.963 |
| 3 | SRR1375907 | GTEX | — | 0.963 |
| 4 | SRR1403915 | GTEX | — | 0.960 |
| 5 | SRR663453 | GTEX | — | 0.960 |
| 6 | SRR1410934 | GTEX | — | 0.957 |
| 7 | SRR1447986 | GTEX | — | 0.957 |
| 8 | SRR1327975 | GTEX | — | 0.957 |
| 9 | SRR1315842 | GTEX | — | 0.956 |
| 10 | SRR1393068 | GTEX | — | 0.956 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.200 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.179 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.148 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.142 | Remibrutinib | — uncovered |
| MYC_TARGETS_V2 | 0.134 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.123 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.112 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.075 | Idelalisib | — uncovered |
| ANDROGEN_RESPONSE | 0.036 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.024 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.021 | Inavolisib | — uncovered |